Evidence map›Paper›PMID 42477718›Full record

ArticleSubstance abuse treatment, prevention, and policy2026

Managing benzodiazepine dependence arising from use of the adulterated opioid supply: a commentary.

Gurkiran Parmar, Nicole Malette, Josey Ross, Alexis Crabtree, Paxton Bach

Abstract read
In one paragraph

Article in Substance abuse treatment, prevention, and policy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gurkiran ParmarBC Centre on Substance Use, Vancouver, BC, Canada.
Nicole MaletteBC Centre on Substance Use, Vancouver, BC, Canada. Nicole.malette@bccsu.ubc.ca.
Josey RossBC Centre on Substance Use, Vancouver, BC, Canada.
Alexis CrabtreeBC Centre for Disease Control, Vancouver, Canada.
Paxton BachBC Centre on Substance Use & UBC Department of Medicine, Vancouver, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The growing presence of benzodiazepine-adulterated opioids in the unregulated drug supply poses significant challenges for clinicians treating people with opioid use disorder. This commentary highlights key areas of uncertainty and emerging agreement on screening, risk assessment, withdrawal timelines, and treatment approaches for individuals using benzodiazepine-adulterated opioids. It also identifies gaps in community-based support, the effectiveness of drug checking, and the role of medications for opioid use disorder in managing opioid-benzodiazepine withdrawal. Together, these scenarios demonstrate rapidly evolving challenges and the need to refine clinical practices in order to improve care for individuals affected by the evolving unregulated drug supply.

Indexed as

Analgesics, OpioidBenzodiazepinesDrug ContaminationOpioid-Related DisordersSubstance-Related DisordersHumansSubstance Withdrawal SyndromeAnalgesics, OpioidBenzodiazepinesAdulterantsBenzodiazepinesOpioidsStreet drugs

Identifiers

PMID42477718
PMCPMC13383429

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.