Evidence map›Paper›PMID 42477664›Full record

ArticleBMC musculoskeletal disorders2026

Association of dietary approaches to stop hypertension, genetic predisposition, and the risk of musculoskeletal disorders: a prospective cohort study.

Bin Yang, Di Zhang, Xin Song, Xiaofeng Ma, Sirui Zheng, Rong Xiang, Xunying Zhao, Yang Qu, Tao Han, Ting Yu and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Bin YangDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Di ZhangDepartment of Epidemiology and Biostatistics, , Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Xin SongDepartment of Epidemiology and Biostatistics, , Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Xiaofeng MaDepartment of Epidemiology and Biostatistics, , Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Sirui ZhengDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Rong XiangDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Xunying ZhaoDepartment of Epidemiology and Biostatistics, , Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Yang QuDepartment of Epidemiology and Biostatistics, , Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Tao HanDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Ting YuDepartment of Epidemiology and Biostatistics, , Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Jinyu ZhouDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Maoyao XiaDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Yangdan ZhongDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Zihao LiDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Ye JuDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Yuqi PangDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Hongxia XiaDepartment of Epidemiology and Biostatistics, , Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Ben ZhangDepartment of Epidemiology and Biostatistics, , Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Mengyu FanDepartment of Epidemiology and Biostatistics, , Institute of Systems Epidemiology, and West China-PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China. fanmengyu@scu.edu.cn.
Xia JiangDepartment of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China. xiajiang@scu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo investigate the associations of the Dietary Approaches to Stop Hypertension (DASH) diet with the incidence of overall and specific musculoskeletal (MSK) disorders, taking genetic predispositions into account.

methodsStudy populations included 115,692 participants. DASH diet scores were calculated using the Oxford WebQ dietary questionnaire, and poly-genetic risk scores (PRS) were calculated summing weighted risk alleles. Cox regressions were performed to evaluate the associations between DASH diet, PRS, and incidence of MSK disorders. The primary outcome was overall disease defined as any of MSK disorders. The secondary outcomes were five major specific conditions, including osteoarthritis, rheumatoid arthritis, gout, low back pain, and neck pain.

resultsDuring a median follow-up period of 11.64 years, 33,230 incident cases of overall MSK disorders were observed. Each 5-point increment in the DASH diet score was associated with a modest 2-4% reduced risk of overall MSK disorders, consistent across three models (Model 1: HR = 0.96, 95%CIs = 0.95-0.97; Model 2: HR = 0.98, 95%CIs = 0.97-0.99; Model 3: HR = 0.98, 95%CIs = 0.97-0.99) as well as different genetic risk groups (low: HR = 0.95, 95%CIs = 0.87-1.03; moderate: HR = 0.98, 95%CIs = 0.94-1.03; high: HR = 0.95, 95%CIs = 0.87-1.03). No gene-diet interaction was identified. When extending to the five specific MSK disorders, a similar pattern of results was observed, except for RA and gout.

conclusionsAdherence to DASH diet is associated with a modestly reduced risk of overall MSK disorders in European populations. In disease-specific analyses, protective associations were observed for OA, low back pain, and neck pain, whereas associations with RA and gout were less consistent. The protective association is broadly consistent across most genetic risk strata, although a potential interaction was noted for RA.

Indexed as

Dietary Approaches To Stop HypertensionGenetic Predisposition to DiseaseMusculoskeletal DiseasesAdultAgedFemaleFollow-Up StudiesGenetic Risk ScoreHumansIncidenceMaleMiddle AgedProspective StudiesRisk FactorsCohort studyDietary Approaches to Stop HypertensionMusculoskeletal DiseasesPolygenic risk score

Identifiers

PMID42477664

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.