Evidence map›Paper›PMID 42477563›Full record

ArticleBMC cardiovascular disorders2026

Appendiceal-source Klebsiella pneumoniae iliac pseudoaneurysm with rupture risk: a three-case series highlighting post-EVAR reassessment.

Bingjing Chen, Jingyu Ji, Yiqing Li, Qin Li, Chao Yang, Yujie Wang

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In one paragraph

Article in BMC cardiovascular disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Bingjing ChenDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jingyu JiDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yiqing LiDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Qin LiDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Chao YangDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yujie WangDepartment of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. wyj2017@hust.edu.cn.

Funding

2025 Intramural Scientific Research Fund - Free Innovation Pre-research Fund of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 2025XHYN034National Natural Science Foundation of China 82570563
6 · The paper itself

Abstract

backgroundInfective native aorto-iliac aneurysms and pseudoaneurysms are uncommon but life-threatening vascular infections. In rupture-prone presentations, emergency endovascular aneurysm repair (EVAR) may be required to reduce the immediate risk of hemorrhage, but technical exclusion of the aneurysm does not establish infection control. CASE PRESENTATION: We report three patients with rupture or impending rupture of infective native aorto-iliac aneurysms who underwent emergency EVAR followed by post-procedural reassessment for residual infection. Case 1 was a 66-year-old woman with type 2 diabetes who presented with lower abdominal pain, leukocytosis, elevated C-reactive protein, and a gas-containing left common iliac pseudoaneurysm. Blood anaerobic culture grew Klebsiella pneumoniae with susceptibility to imipenem, meropenem, ceftazidime, cefoperazone-sulbactam, and ceftazidime-avibactam, while urine cultures were negative. Although endovascular exclusion was technically successful, persistent inflammatory signals prompted reassessment and subsequent source-control management. Perforated appendicitis with retroperitoneal contamination supported appendiceal-source contiguous spread to the iliac artery. Case 2 involved a distal abdominal aortic infected pseudoaneurysm with rupture near the inferior mesenteric artery origin; persistent peri-aortic fluid after EVAR required laparoscopic hematoma evacuation and lesion resection. Case 3 involved an infrarenal infected aortic pseudoaneurysm with bilateral common iliac involvement; delayed fever, Escherichia coli bacteremia, and right iliac limb occlusion led to thrombectomy, which retrieved inflammatory fibrinous debris.

conclusionsIn infective native aorto-iliac aneurysms, emergency EVAR can control the immediate risk of rupture, but exclusion of the aneurysm does not eradicate infection. After EVAR, persistent fever, pain, elevated inflammatory markers, bacteremia, or peri-graft fluid or gas should prompt a search for a residual or occult gastrointestinal, retroperitoneal, or urinary source. An appendiceal source of Klebsiella pneumoniae iliac pseudoaneurysm is rare, and recognizing it may allow timely source control. The short follow-up and small number of patients limit broader conclusions.

Indexed as

Aneurysm, InfectedAneurysm, RupturedAortic Aneurysm, AbdominalAppendicitisEndovascular Aneurysm RepairKlebsiella InfectionsKlebsiella pneumoniaeAgedAneurysm, FalseAnti-Bacterial AgentsAppendectomyBlood Vessel Prosthesis ImplantationFemaleHumansIliac AneurysmRisk FactorsAnti-Bacterial AgentsAppendicitisCase seriesEndovascular aneurysm repairIliac pseudoaneurysmInfective native aortic aneurysmKlebsiella pneumoniaeSource control

Identifiers

PMID42477563
PMCPMC13673834

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.