ArticleBMC plant biology2026
Disruption of SlCNGC18 enhances Cucumber mosaic virus resistance and drought tolerance in tomato (Solanum lycopersicum L. cv. Micro-Tom).
Article in BMC plant biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
Abstract
backgroundTomato is a globally important crop that is frequently affected by stress linked to viral infection and drought, both of which significantly reduce yield and quality. Cucumber mosaic virus (CMV) is a major pathogen that induces severe disease symptoms, while drought limits plant growth and productivity in general. Calcium signaling through cyclic nucleotide-gated channels (CNGCs) plays a critical role in plant responses to both biotic and abiotic stresses. However, it remains unclear how the tomato SlCNGC18, a homolog of Arabidopsis thaliana CNGC4 (DND2), regulates viral resistance and drought tolerance in Micro-Tom plants.
resultsUsing CRISPR/Cas9 gene editing, we generated loss-of-function slcngc18 mutants in tomato (cv. Micro-Tom) and assessed their responses to CMV infection. Drought-related responses were further evaluated using the slcngc18-2 mutant. The mutants showed enhanced resistance to CMV, with more than a threefold reduction in viral accumulation and milder disease symptoms. This resistance was accompanied by a twofold increase in salicylic acid (SA) levels and induction of the defense gene SlPR1, which showed more than sevenfold upregulation. Consistently, SlPBS3 was also upregulated, suggesting its contribution to increased SA levels. Moreover, under drought conditions, slcngc18-2 plants showed approximately sevenfold higher survival rates and reduced water loss compared with wild-type plants. Physiological analyses revealed altered stomatal traits, characterized by smaller stomata with increased stomatal density, along with enhanced abscisic acid (ABA) signaling despite no change in ABA levels. Furthermore, transcriptome profiling indicated downregulation of genes involved in calcium transport and phenylalanine ammonia-lyase.
conclusionsOur results indicate that SlCNGC18 functions as a negative regulator of CMV resistance and drought tolerance-related responses in Micro-Tom. The slcngc18 mutants exhibited elevated SA levels together with enhanced ABA signaling-related gene expression, supporting SlCNGC18 as a promising target for breeding tomato cultivars with improved resilience to multiple stresses. Overall, this study provides new insight into the potential involvement of calcium channel-mediated signaling in hormonal and immune responses during crop stress adaptation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.