ArticleNature communications2026
Delineating the risk factors, sources of acquisition and clinical outcomes in neonates colonised with multidrug-resistant bacteria: the NeoCol study.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Neonatal Unit Colonization Pressure and Acquisition of Extended-Spectrum β-Lactamase Gut Colonization.JAMA network open · 2026Article
- Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
Antimicrobial resistance contributes to neonatal mortality globally. Delineating transmission pathways resulting in neonatal colonisation with multidrug-resistant (MDR) bacteria is necessary to reduce this burden. We conducted a prospective cohort study of 189 mother-infant dyads to identify the risk factors associated with transmission of MDR bacteria, revealing a high prevalence of maternal colonisation with MDR bacteria at delivery (63%, 120/189), and in neonates by hospital discharge (61%, 115/189). However, maternal colonisation with carbapenem-resistant Enterobacterales (CRE) was low (3%, 6/189) whereas CRE acquisition occurred at a median time point of 13 days in hospitalised neonates (26%, 50/189), suggesting horizontal transmission of CRE predominates. Compared to non-colonised neonates, those colonised with MDR bacteria were more likely to have been exposed to antibiotics prior to colonisation (63%, vs 24%, p < 0.001), require a longer hospital stay (16 days vs 2 days, p < 0.001) and have episodes of sepsis following colonisation (62% vs 24%, p < 0.001). However, most culture-positive neonatal infections (91%, 10/11) were not caused by previously identified colonising bacteria. Our study reveals poor clinical outcomes associated with MDR neonatal colonisation, and suggests improved antibiotic stewardship strategies may reduce this burden.
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Registered trials
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