Evidence map›Paper›PMID 42477336›Full record

ArticleNature communications2026

Towards an enzyme cascade synthesis of the bulk chemical acrylic acid.

Haodong Zhao, Chunying Wang, Shiqing Zhang, Qian Wang, Huanyu Chu, Jinying Yang, Lei Zhang, Zhanmei Xu, Bingzhao Zhuo, Cui Liu and 8 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Haodong Zhao *Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Chunying Wang *Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Shiqing Zhang *Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Qian Wang *Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Huanyu ChuTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.ORCID http://orcid.org/0000-0002-9883-8850
Jinying YangDivision of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China.
Lei ZhangTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Zhanmei XuTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Bingzhao ZhuoTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Cui LiuTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.ORCID http://orcid.org/0000-0002-9035-3066
Yufeng MaoTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.ORCID http://orcid.org/0000-0002-4598-2939
Lina LuCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Xu ZhangTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.ORCID http://orcid.org/0009-0009-7401-1160
Huiru ZhaoCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, China.
Yanhe MaTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Xiang ShengTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China. shengx@tib.cas.cn.ORCID http://orcid.org/0000-0002-6542-6649
Yuwan LiuTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China. liu_yw@tib.cas.cn.ORCID http://orcid.org/0000-0001-8200-3077
Huifeng JiangTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China. jiang_hf@tib.cas.cn.ORCID http://orcid.org/0000-0002-3757-7896

Funding

National Natural Science Foundation of China (National Science Foundation of China) NSFC-32001030
6 · The paper itself

Abstract

Acrylic acid is a bulk chemical predominantly produced via fossil-based processes. Here, we repurpose and engineer a thiamine diphosphate (ThDP)-dependent enzyme to catalyze direct

Indexed as

AcrylatesBiocatalysisDirected Molecular EvolutionMethanolThiamine PyrophosphateAcrylatesacrylic acidMethanolThiamine Pyrophosphate

Identifiers

PMID42477336
PMCPMC13500476

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.