Evidence map›Paper›PMID 42477234›Full record

ArticleGeroScience2026

Performance of the SmartMe&You serious video games for home telemonitoring is related to cognitive status and resting-state electroencephalographic markers in healthy and Parkinson's disease participants.

Claudio Del Percio, Roberta Lizio, Mina De Bartolo, Matteo Carpi, Giuseppe Noce, Susanna Lopez, Antonio Pio Afragola, Federica Fiorentino, Filippo Carducci, Veronica Henao Isaza and 27 more

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Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Frailty in Parkinson's disease: time to integrate it into treatment decision-making?Journal of neural transmission (Vienna, Austria : 1996) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Claudio Del PercioDepartment of Physiology and Pharmacology "Vittorio Erspamer, Sapienza University of Rome, P. Le A. Moro 5, 00185, Rome, Italy.
Roberta LizioDepartment of Physiology and Pharmacology "Vittorio Erspamer, Sapienza University of Rome, P. Le A. Moro 5, 00185, Rome, Italy. roberta.lizio@uniroma1.it.ORCID http://orcid.org/0000-0003-1262-3689
Mina De BartoloDepartment of Physiology and Pharmacology "Vittorio Erspamer, Sapienza University of Rome, P. Le A. Moro 5, 00185, Rome, Italy.
Matteo CarpiDepartment of Physiology and Pharmacology "Vittorio Erspamer, Sapienza University of Rome, P. Le A. Moro 5, 00185, Rome, Italy.
Giuseppe NoceIRCCS Synlab SDN, Naples, Italy.
Susanna LopezDepartment of Physiology and Pharmacology "Vittorio Erspamer, Sapienza University of Rome, P. Le A. Moro 5, 00185, Rome, Italy.
Antonio Pio AfragolaDepartment of Physiology and Pharmacology "Vittorio Erspamer, Sapienza University of Rome, P. Le A. Moro 5, 00185, Rome, Italy.
Federica FiorentinoDepartment of Physiology and Pharmacology "Vittorio Erspamer, Sapienza University of Rome, P. Le A. Moro 5, 00185, Rome, Italy.
Filippo CarducciDepartment of Physiology and Pharmacology "Vittorio Erspamer, Sapienza University of Rome, P. Le A. Moro 5, 00185, Rome, Italy.
Veronica Henao IsazaDepartment of Physiology and Pharmacology "Vittorio Erspamer, Sapienza University of Rome, P. Le A. Moro 5, 00185, Rome, Italy.
Paolo BaroneIRCCS Synlab SDN, Naples, Italy.
Arianna CappielloCenter for Neurodegenerative Diseases, CEMAND, UNISA, Salerno, Italy.
Federico Di FilippoCenter for Neurodegenerative Diseases, CEMAND, UNISA, Salerno, Italy.
Dora RiemmaCenter for Neurodegenerative Diseases, CEMAND, UNISA, Salerno, Italy.
Giuliana CostanzoCenter for Neurodegenerative Diseases, CEMAND, UNISA, Salerno, Italy.
Simone CauzzoParkinson and Movement Disorders Unit, Study Center for Neurodegeneration (CESNE), Center for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, University of Padua, Padua, Italy.
Eleonora FiorenzatoParkinson and Movement Disorders Unit, Study Center for Neurodegeneration (CESNE), Center for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, University of Padua, Padua, Italy.
Francesca VianelloParkinson and Movement Disorders Unit, Study Center for Neurodegeneration (CESNE), Center for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, University of Padua, Padua, Italy.
Fabrizio StocchiIRCCS San Raffaele, Rome, Italy.
Chiara ColettiIRCCS San Raffaele, Rome, Italy.
Laura VaccaIRCCS San Raffaele, Rome, Italy.
Francesco InfarinatoIRCCS San Raffaele, Rome, Italy.
Paola RomanoIRCCS San Raffaele, Rome, Italy.
Giacomo Maria RussoSentech S.R.L, Rome, Italy.
Lorenzo AngeloniSentech S.R.L, Rome, Italy.
Andrea RosatiSogetel S.R.L, Rome, Italy.
Andrea BaldasSogetel S.R.L, Rome, Italy.
Vittorio Luigi DianaSogetel S.R.L, Rome, Italy.
Delia PassalaquaConsortium GARR, Rome, Italy.
Maria Francesca De PandisCenter for the Diagnosis and Care of Parkinson's Disease, IRCCS San Raffaele Roma, Cassino Site, Cassino, FR, Italy.
Simone MarzialiIRCCS San Raffaele, Rome, Italy.
Sabrina TomassiniConsortium GARR, Rome, Italy.
Franco GiubileiDepartment of Neuroscience, Mental Health, and Sensory Organs, Sapienza University of Rome, Rome, Italy.
Lavinia NardaDepartment of Neuroscience, Mental Health, and Sensory Organs, Sapienza University of Rome, Rome, Italy.
Angelo AntoniniParkinson and Movement Disorders Unit, Study Center for Neurodegeneration (CESNE), Center for Rare Neurological Diseases (ERN-RND), Department of Neuroscience, University of Padua, Padua, Italy.
Angelo BaroneCenter for Neurodegenerative Diseases, CEMAND, UNISA, Salerno, Italy.
Claudio BabiloniDepartment of Physiology and Pharmacology "Vittorio Erspamer, Sapienza University of Rome, P. Le A. Moro 5, 00185, Rome, Italy.

Funding

HORIZON EUROPE Framework Programme Grant Agreement: GAP-101058516Lazio Innova Grant Agreement: F89J23001180007Ministero della Salute PNRR-MAD-2022-12376415Ministero dell'Istruzione, dell'Università e della Ricerca CUP B53C23002080006Ministero dell'Istruzione, dell'Università e della Ricerca CUP B83C22002820006Ministero dell'Istruzione, dell'Università e della Ricerca Grant Agreement: 2022FJAXY8
6 · The paper itself

Abstract

Unsupervised serious video games on the SmartMe&You home telemonitoring platform may enable the assessment of cognitive fluctuations in older individuals, with or without cognitive deficits. Here, we tested their validity in cognitively unimpaired older adults (Healthy) and patients with mild cognitive impairment and mild to moderate dementia due to Parkinson's disease (PDCD). Such validity was assessed using Mini-Mental State Examination (MMSE) scores and resting-state eyes-closed electroencephalography (rsEEG) activity. Clinical, demographic, and rsEEG datasets were collected from 34 healthy and 68 PDCD participants. The SmartMe&You video games included 7 unsupervised cognitive tasks implemented on a commercial tablet. The rsEEG source activities in the individual delta, theta, and alpha frequency bands were estimated using the eLORETA freeware. As novel findings, we showed that game performance: (1) discriminated between healthy participants and PDCD patients, with overall accuracy exceeding 90%; (2) was positively associated with MMSE scores across all participants (p < 0.00001); and (3) was negatively associated with global rsEEG source activity in the delta and theta frequency bands (p < 0.00001). These findings suggest that serious videogames of the SmartMe&You home telemonitoring platform were feasible and sensitive to cognitive status across the spectrum from normal aging to Parkinson's disease-related dementia. This approach provides a scalable, low-cost, and ecologically valid tool for remote cognitive monitoring, with future potential applications in both early detection and longitudinal tracking of cognitive decline.

Indexed as

Exact low-resolution brain electromagnetic source tomography (eLORETA)Parkinson’s diseaseResting-state electroencephalographic (EEG) rhythmsSmartMe&You serious video games

Identifiers

PMID42477234

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.