ArticleNaunyn-Schmiedeberg's archives of pharmacology2026
Identification of miR-21-5p and miR-21-3p regulated hub genes and drug repurposing targets in cervical cancer: an integrative computational analysis.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Cervical cancer remains a major cause of cancer-related mortality in women, and there is limited understanding of strand-specific miRNA regulation. This study investigated the differential regulatory roles of miR-21-5p and miR-21-3p and their associated gene networks using an integrative computational approach. A total of 664 experimentally validated targets for miR-21-5p and 3663 for miR-21-3p were identified, with 628 and 99 strand-specific targets, respectively, and five overlapping genes (SPRY1, STAT3, CLIP4, SMAD7, and PPARA). Expression analysis using TCGA-CESC data demonstrated consistent upregulation of miR-21 across all clinical subgroups, independent of age, stage, and histological subtypes. Protein-protein interaction analysis revealed a dense network for miR-21-5p (559 nodes, 3252 edges) compared to that for miR-21-3p (4 nodes, 133 edges), indicating a broader regulatory influence of the 5p strand. Five hub genes (TP53, PTEN, EGFR, STAT3, and CCND1) were identified, with PTEN and EGFR common to both strands. Differential expression analysis showed downregulation of PTEN and upregulation of CCND1, EGFR (p = 1.83 × 10⁻
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