Evidence map›Paper›PMID 42477142›Full record

ArticleActa pharmacologica Sinica2026

Synthetic cannabinoid receptor agonists inhibit the cardiac voltage-gated potassium channel hERG.

Nina E Ottosson, Damon J A Frampton, Tanadet Pipatpolkai, Caitlyn Norman, Urban Karlsson, Amaia Jauregi-Miguel, Maryke Venter, Akshay Sridhar, H Peter Larsson, Henrik Gréen and 1 more

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Article in Acta pharmacologica Sinica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nina E Ottosson *Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Damon J A Frampton *Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Tanadet Pipatpolkai *School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore. tanadet.pipatpolkai@ntu.edu.sg.
Caitlyn NormanDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Urban KarlssonDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Amaia Jauregi-MiguelDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Maryke VenterDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Akshay SridharDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
H Peter LarssonDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Henrik GréenDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Sara I LiinDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden. sara.liin@liu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic cannabinoid receptor agonists (SCRAs) are a large group of structurally diverse designer drugs (analogues of controlled substances) associated with intense and sometimes fatal intoxication. Cardiac symptoms, including tachycardia and arrhythmia, are common consequences of SCRA consumption. However, little is known about the mechanisms through which SCRAs may perturb cardiac rhythm. Here, we used electrophysiological techniques to screen 36 SCRAs on two ion channels responsible for cardiomyocyte repolarization, hERG (also called K

Indexed as

Cannabinoid Receptor AgonistsERG1 Potassium ChannelPotassium Channel BlockersPotassium Channels, Voltage-GatedAnimalsBinding SitesHEK293 CellsHumansMyocytes, CardiacStructure-Activity RelationshipCannabinoid Receptor AgonistsERG1 Potassium ChannelKCNE1 protein, humanKCNH2 protein, humanPotassium Channel BlockersPotassium Channels, Voltage-GatedarrhythmiaelectrophysiologyKCNQ1molecular dynamics

Identifiers

PMID42477142
PMCPMC13586173

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.