Evidence map›Paper›PMID 42477129›Full record

ReviewAdvances in biochemical engineering/biotechnology2026

Metabolic Engineering of Microbial Strains for 1,2,4-Butanetriol Production: Progress and Future Perspectives.

Wei-Bin Wang, Meng-Rui Tao, Kai Li, Takahiro Bamba, Cheng Cheng, Tomohisa Hasunuma, Akihiko Kondo, Nuttha Thongchul, Shuai Zhao, Jia-Xun Feng and 2 more

Abstract readReview
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In one paragraph

Review in Advances in biochemical engineering/biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wei-Bin WangState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Meng-Rui TaoState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Kai LiState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Takahiro BambaEngineering Biology Research Center, Kobe University, Kobe, Japan.
Cheng ChengSchool of Biotechnology and Food Engineering, Hefei Normal University, Hefei, China.
Tomohisa HasunumaEngineering Biology Research Center, Kobe University, Kobe, Japan.
Akihiko KondoEngineering Biology Research Center, Kobe University, Kobe, Japan.
Nuttha ThongchulInstitute of Biotechnology and Genetic Engineering, Chulalongkorn University, Bangkok, Thailand.
Shuai ZhaoState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi Research Center for Microbial and Enzyme Engineering Technology, College of Life Science and Technology, Guangxi University, Nanning, Guangxi, China.
Jia-Xun FengState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi Research Center for Microbial and Enzyme Engineering Technology, College of Life Science and Technology, Guangxi University, Nanning, Guangxi, China.
Xin-Qing ZhaoState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China. xqzhao@sjtu.edu.cn.
Feng-Wu BaiState Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sustainable production of biofuels and biochemicals from renewable biomass represents a promising alternative to fossil-based feedstocks, offering significant benefits for low-carbon economies and environmental protection. The biochemical 1,2,4-butanetriol (BT) is an important short-chain chiral triol, which is widely used as pharmaceuticals, industrial foam, anticorrosion additives, and plasticizers. Although biosynthesis of BT has been achieved in various engineered microbes, achieving cost-competitive production remains a significant challenge. This chapter focuses on research progress in metabolic engineering of BT production, which mainly includes (1) design of BT biosynthetic pathways for expression in bacterial and yeast cell factories, (2) current metabolic engineering and process optimization strategies to optimize BT production, and (3) utilizing lignocellulosic biomass as a sustainable feedstock for BT production. In addition, future prospects on enhancing BT production efficiency through advanced metabolic engineering and synthetic biology approaches integrating with artificial intelligence (AI)-based technologies are also presented.

Indexed as

BacteriaButanolsMetabolic EngineeringBiofuelsBiofuelsButanols1,2,4-Butanetriol (BT)Glucose and xyloseLignocellulosic biomassMetabolic engineeringMicrobial cell factories

Identifiers

PMID42477129

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.