ArticleJournal of perinatology : official journal of the California Perinatal Association2026
Early echocardiographic markers following deferred cord clamping with high or low oxygen in extremely low gestation infants (DOXIE-Echo).
Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Umbilical cord management in newborn resuscitation: a systematic review and meta-analysis.Pediatric research · 2025Pooled it
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Deferred cord clamping (DCC) with adequate ventilation improves cardiovascular transition and survival. Brief use of 100% oxygen during neonatal resuscitation may enhance ventilation and reduce pulmonary vascular resistance.
objectiveDetermine whether high oxygen (HI, 100%) versus low oxygen (LO, 30%) support during DCC affects postnatal hemodynamics in extremely preterm infants.
methodsIn this double-blinded randomized sub-study, infants born at 23⁰-27⁶ weeks' gestation received respiratory support with HI or LO oxygen during 90 s of DCC. After cord clamping, all infants were managed per standard guidelines. An echocardiogram was performed within 12 postnatal hours to assess cardiac function.
resultsBaseline characteristics of 110 infants (51 HI, 59 LO) were similar. Right ventricular output did not differ between groups (293 ± 105 vs 268 ± 71 ml/kg/min; p = 0.17), nor did additional measures of cardiac function.
conclusionsUse of 100% oxygen during DCC did not adversely affect early transitional hemodynamics compared with 30% oxygen.
Identifiers
42477100What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.