Evidence map›Paper›PMID 42477036›Full record

ArticleCommunications biology2026

CCR7-PERK-CREB3L1 signaling mediates tumor-associated macrophages-derived SPP1 promotion of oral squamous cell carcinoma.

Shanfeng Lin, Tian Li, Weiqi Li, Cong Yan, Wanhang Zhou, Haoxuan Wu, Zengxu Wang, Zhenning Li, Changfu Sun, Fayu Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shanfeng Lin *Department of Oroamxillofacial-Head and Neck Surgery, School and Hospital of Stomatology, China Medical University, Shenyang, China.
Tian Li *Liaoning Province Key Laboratory of Oral Disease, Shenyang, China.
Weiqi Li *State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, Sichuan University, Chengdu, China.
Cong YanDepartment of Oroamxillofacial-Head and Neck Surgery, School and Hospital of Stomatology, China Medical University, Shenyang, China.
Wanhang ZhouDepartment of Oroamxillofacial-Head and Neck Surgery, School and Hospital of Stomatology, China Medical University, Shenyang, China.
Haoxuan WuDepartment of Oroamxillofacial-Head and Neck Surgery, School and Hospital of Stomatology, China Medical University, Shenyang, China.
Zengxu WangDepartment of Oroamxillofacial-Head and Neck Surgery, School and Hospital of Stomatology, China Medical University, Shenyang, China.
Zhenning LiDepartment of Oroamxillofacial-Head and Neck Surgery, School and Hospital of Stomatology, China Medical University, Shenyang, China.
Changfu SunDepartment of Oroamxillofacial-Head and Neck Surgery, School and Hospital of Stomatology, China Medical University, Shenyang, China.
Fayu LiuDepartment of Oroamxillofacial-Head and Neck Surgery, School and Hospital of Stomatology, China Medical University, Shenyang, China. 20031060@cmu.edu.cn.ORCID 0000-0003-4314-6133

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemokine receptor type 7 (CCR7) is extensively implicated in the regulation of inflammatory signaling. Although CCR7 is frequently overexpressed in malignant epithelial cells, its immunomodulatory role in tumor-associated macrophages (TAMs) and its contribution to oral squamous cell carcinoma (OSCC) progression remain poorly defined. To investigate the functional relevance of CCR7 in TAMs, we establish a CCR7-deficient (Ccr7

Indexed as

Carcinoma, Squamous CellCyclic AMP Response Element-Binding ProteinMouth NeoplasmsReceptors, CCR7Tumor-Associated MacrophagesAnimalsCell Line, TumorGene Expression Regulation, NeoplasticHumansMiceSignal TransductionCcr7 protein, mouseCyclic AMP Response Element-Binding ProteinReceptors, CCR7

Identifiers

PMID42477036
PMCPMC13550601

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.