Evidence map›Paper›PMID 42477008›Full record

ArticleScientific reports2026

Alterations in sensory and motor nerve conduction associated with age and osteoarthritis in cats are correlated with functional impairment and somatosensory sensitization.

Aude Castel, Aliénor Delsart, Colombe Otis, Manuela Lefort-Holguin, Karol-Ann Henry, Maxim Moreau, Bertrand Lussier, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Eric Troncy

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Aude Castel *Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada. aude.castel@umontreal.ca.ORCID https://orcid.org/0000-0002-4895-6170
Aliénor Delsart *Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.
Colombe OtisGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.
Manuela Lefort-HolguinGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.
Karol-Ann HenryDepartment of Clinical Sciences, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC, Canada.
Maxim MoreauGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.
Bertrand LussierGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.
Johanne Martel-PelletierGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.
Jean-Pierre PelletierGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.
Eric TroncyGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, Saint-Hyacinthe, QC, Canada.

Funding

Morris Animal Foundation D33FE-301
6 · The paper itself

Abstract

Feline somatosensory impairments associated with aging and osteoarthritis (OA) can be quantified through quantitative sensory testing and nerve conduction (NC). This prospective, randomized and blinded study aimed to compare NC in young healthy (CTRL, n = 6) and older OA (OLD, n = 12) cats. Under temperature-controlled general anesthesia, amplitude and conduction velocity (CV) of mixed tibial/sciatic and ulnar nerves were measured. Structural changes (radiographic score), functional alterations [MI-CAT(V)], neuro-sensitization [paw withdrawal threshold (PWT); and response to mechanical temporal summation (RMTS)] were assessed. Data distribution determined tests for inter-group comparison, and outcome correlations (α = 5%). OLD cats presented higher radiographic and MI-CAT(V) scores, but lower PWT, RMTS, motor CV (-23%), motor (-35%) and sensory (-45%) amplitudes compared to CTRL. Functional alterations correlated strongly with structural changes (r = 0.74, p < 0.001) and age (r = 0.90, p < 0.001), and moderately with neuro-sensitization (p < 0.016). Radiographic and MI-CAT(V) scores correlated negatively with (distal) motor CVs (p < 0.044), and with some motor and sensory amplitudes (p < 0.028). The PWTs correlated positively to motor CVs (p < 0.045). Older OA cats exhibited NC alterations correlated with neuro-sensitization and higher than expected with age alone.

Indexed as

Distal neuropathyElectrodiagnosticFelineMI-CAT(V)Paw withdrawal thresholdvon Frey

Identifiers

PMID42477008
PMCPMC13683033

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.