ArticleScientific reports2026
Genomic surveillance of multidrug-resistant Enterobacterales in a long-term care facility in Northern Italy based on a point prevalence screening.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Long-term care facilities (LTCFs) are increasingly recognised as settings where multidrug-resistant organisms (MDROs) persist and circulate. A point prevalence screening study conducted in 2022 in an LTCF in the Autonomous Province of Bolzano/Bozen, Northern Italy, provided a collection of MDR Enterobacterales isolates from residents and staff. This study aimed to characterise the clonal structure, transmission dynamics, and resistance mechanisms of these isolates through high-resolution genomic analysis. Whole-genome sequencing was performed on third-generation cephalosporin- and/or carbapenem-resistant isolates of Klebsiella pneumoniae, Escherichia coli, Morganella morganii, and Proteus mirabilis. Isolates underwent core genome multilocus sequence typing, phylogenetic reconstruction, and resistance gene profiling using Kleborate and ResFinder. K. pneumoniae isolates formed five major clusters, with ST39 confined to a single section, suggesting intra-section transmission. ST405 and ST307, both high-risk clones, were also detected, with ST307 harbouring the carbapenemase gene bla
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