ArticleNature communications2026
Synthesis of poly(4HB-co-PhLA) and poly(3HB-co-4HB-co-PhLA) as sustainable hot-melt adhesives using engineered Escherichia coli.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Synthesis of poly(4HB-co-PhLA) and poly(3HB-co-4HB-co-PhLA) as sustainable hot-melt adhesives using engineered Escherichia coli.Nature communications · 2026Article
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4 authors.
Funding
Abstract
Conventional petroleum-based adhesives are non-biodegradable and raise environmental concerns. Polyhydroxyalkanoates (PHAs), bacterial polyesters synthesized from renewable carbon sources, are promising adhesive candidates due to biodegradability and structural diversity. Here, we report aromatic PHA copolymers, poly[4-hydroxybutyrate(4HB)-co-phenyllactate(PhLA)] and poly[3-hydroxybutyrate(3HB)-co-4HB-co-PhLA], exhibiting thermal stability and hot-melt adhesive (HMA) properties. Escherichia coli strains are engineered to produce these polymers from glucose and polymer biosynthesis is enhanced by optimizing heterologous expression, introducing additional CoA transferases and temporally regulating gene expression. We applied in silico simulations to systematically identify engineering targets that improve the synthesis of multiple monomers. The final engineered strains produce 10.2 g l
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