Evidence map›Paper›PMID 42476598›Full record

ArticleBMJ case reports2026

β

William Stobie, Farmey Joseph

Abstract readCase Reports
In one paragraph

Article in BMJ case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

William StobieDepartment of Obstetrics and Gynaecology, Lismore Base Hospital, Lismore, New South Wales, Australia.ORCID http://orcid.org/0000-0003-2637-2315
Farmey JosephDepartment of Obstetrics and Gynaecology, Lismore Base Hospital, Lismore, New South Wales, Australia farmey.joseph@health.nsw.gov.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

β₂-agonist toxicity is a rare complication of asthma treatment, but there is little information about its interplay in pregnancy with maternal and fetal physiology. This case describes a woman in her early 30s at 37 weeks gestation with supratherapeutic use of inhaled salbutamol and salmeterol in the setting of worsening shortness of breath in the third trimester of pregnancy. She presented to the emergency department with chest discomfort and shortness of breath with a raised maternal lactate and troponin. Fetal cardiotocography was abnormal, so birth was expedited by emergency caesarean section due to concerns for fetal distress secondary to β₂-agonist toxicity. This case highlights the risks of inhaled β₂-agonist toxicity in pregnancy, which can be associated with troponin rise and fetal distress, even in the absence of a severe asthma exacerbation. It also highlights the importance of antenatal asthma education to ensure care is appropriately escalated when needed.

Indexed as

Adrenergic beta-2 Receptor AgonistsAlbuterolAsthmaFetal DistressPregnancy ComplicationsSalmeterol XinafoateTroponinAdministration, InhalationAdultCesarean SectionFemaleHumansPregnancyPregnancy Trimester, ThirdAdrenergic beta-2 Receptor AgonistsAlbuterolSalmeterol XinafoateTroponinAsthmaDrug misuse (including addiction)PregnancyRespiratory systemToxicology

Identifiers

PMID42476598
PMCPMC13385640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.