ArticleThe Journal of pediatrics2026
Birth Weight in Infants with a Cleft Lip and/or Palate: A Systematic Review and Meta-Analysis.
Article in The Journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectiveTo understand the association between birth weight and orofacial cleft (cleft) considering key covariates. STUDY
designWe conducted a systematic review and meta-analysis by searching 7 electronic databases for articles published before February 9, 2025. We used Rayyan systematic review software to screen 5651 identified articles with birth weight estimates on infants with cleft. Two reviewers manually reviewed 296 articles for eligibility; a third reviewer resolved any discrepancies. We extracted data on birth weight (mean and low birth weight [<2500 g]), cleft type (cleft lip, cleft palate, cleft lip, and palate), comorbidity status (yes/no), and country income status (high vs low- or middle-income per World Bank). We used a multilevel mixed-effects model to estimate overall birth weight and birth weight stratified by cleft type, comorbidity status, and country income status.
resultsSixty-three studies were included; 39 studies (66 effect sizes, n = 25 991 infants) reported mean birth weight in infants with cleft. Unadjusted mean birth weight was 3143g (95% CI: 3056, 3231). Mean birth weight was 3405g (95% CI: 3285, 3525) after adjusting for cleft type, comorbidity status, and country income status. Lower birth weight estimates were observed among infants in low- or middle-income (vs high-income) country status and for infants with comorbidities (vs no comorbidities).
conclusionsBirth weight in infants with cleft is similar to global birth weight standards after accounting for country income status and comorbidity status and adjusted birth weight did not differ by cleft type. These findings emphasize the need for close attention to postnatal growth monitoring, feeding, and nutritional interventions among infants with cleft.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.