Evidence map›Paper›PMID 42476196›Full record

ArticleAntiviral research2026

Levosimendan inhibits HIV-1 infection in myeloid cells via counteracting RIOK1.

Jinshan He, Jie Ma, Youngmin Park, Dawei Zhou, Xu Wang, Guillaume N Fiches, Kateepe A S N Shanaka, Thurbu T Lepcha, Yan Liu, Suha Eleya and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Antiviral research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Jinshan HeDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Jie MaDepartment of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Youngmin ParkDivision of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Dawei ZhouDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Xu WangDepartment of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Guillaume N FichesDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Kateepe A S N ShanakaDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Thurbu T LepchaDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Yan LiuDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Suha EleyaDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Netty G SantosoDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Wen-Zhe HoDepartment of Pathology and Laboratory Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, 19140, USA.
Jian ZhuDepartment of Pathology, College of Medicine, The Ohio State University, Columbus, OH, 43210, USA. Electronic address: Jian.Zhu@osumc.edu.

Funding

Investigate Host Gene Isoforms Contributing to HIV Persistence in Cocaine UsersR01DA059538 · NIDA · OHIO STATE UNIVERSITY · PI Wei Jiang, Jian Zhu · 2023 to 2026
$2.9M
Target Host Epigenetic Regulation of HIV Proviruses to Reinforce Viral Deep Latency in MicrogliaR01MH134402 · NIMH · OHIO STATE UNIVERSITY · PI HO, WENZHE, ZHU, JIAN · 2023 to 2025
$2.2M
Target Host Epigenetic Regulation of HIV Proviruses to Reinforce Viral Deep Latency in MicrogliaRF1MH134402 · NIMH · OHIO STATE UNIVERSITY · PI WENZHE HO, Jian Zhu · 2026 to 2026
$1.3M
NIDA NIH HHS R01 DA059538NIMH NIH HHS R01 MH134402NIMH NIH HHS RF1 MH134402
6 · The paper itself

Abstract

Despite the highly potent antiretroviral therapies, HIV-1 establishes persistent infection and causes chronic inflammation in people living with HIV-1 (PLWH). Beyond CD4

Indexed as

Anti-HIV AgentsHIV-1HIV InfectionsMyeloid CellsProtein Serine-Threonine KinasesSimendanCell LineHumansMacrophagesMonocytesVirus ActivationVirus LatencyVirus ReplicationAnti-HIV AgentsProtein Serine-Threonine KinasesSimendanHIVLatencyLevosimendan (LSM)Myeloid cellsRIOK1

Identifiers

PMID42476196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.