Evidence map›Paper›PMID 42475954›Full record

ArticleJournal of the mechanical behavior of biomedical materials2026

Biomechanical function of the murine cervix with elastic fiber deficiency.

Mari J E Domingo, Abigail Fisk, Qinhan Zhou, Avery G Franques, Matthew R Bersi, Kristin S Miller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the mechanical behavior of biomedical materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mari J E DomingoUniversity of Texas at Dallas, Department of Bioengineering, 800 W. Campbell Road, Richardson, TX, 75080, USA.
Abigail FiskWashington University in St. Louis, Department of Mechanical Engineering and Materials Science, 1 Brookings Drive, St. Louis, MO, 63130, USA.
Qinhan ZhouUniversity of Texas at Dallas, Department of Bioengineering, 800 W. Campbell Road, Richardson, TX, 75080, USA.
Avery G FranquesTulane University, Department of Cell and Molecular Biology, 6823 St. Charles Avenue, New Orleans, LA, 70118, USA.
Matthew R BersiWashington University in St. Louis, Department of Mechanical Engineering and Materials Science, 1 Brookings Drive, St. Louis, MO, 63130, USA.
Kristin S MillerUniversity of Texas at Dallas, Department of Bioengineering, 800 W. Campbell Road, Richardson, TX, 75080, USA; University of Texas at Dallas, Department of Mechanical Engineering, 800 W. Campbell Road, Richardson, TX, 75080, USA; University of Texas Southwestern Medical Center, Department of Obstetrics and Gynecology, 5323 Harry Hines Blvd., Dallas, TX, 75390, USA. Electronic address: Kristin.Miller@UTDallas.edu.

Funding

Identification of Age and Injury Dependent Mechanisms of Elastic Fiber Dynamics in the Murine VaginaR01AG086472 · NIA · UNIVERSITY OF TEXAS DALLAS · PI Kristin Suzanne Miller · 2025 to 2026
$1.5M
NIA NIH HHS R01 AG086472
6 · The paper itself

Abstract

Preterm birth (PTB) is the leading cause of infant death globally. Improper softening and dilation of the cervix due to cervical insufficiency is a major contributor to PTB. However, the processes describing why or how the cervix prematurely remodels are not well understood. Elastic fibers and smooth muscle cells contribute to contractile and mechanical stability in soft tissues, but their relationship in the cervix is not fully characterized. Towards this end, this study uses the fibulin-5 global knockout mouse model to investigate the impact of elastic fiber deficiency on the contractile and biomechanical behavior of the cervix. Cervixes from nulliparous fibulin-5 wildtype (Fbln5

Indexed as

Cervix UteriElastic TissueMechanical PhenomenaActinsAnimalsBiomechanical PhenomenaElastinExtracellular Matrix ProteinsFemaleMiceMice, KnockoutRecombinant ProteinsActinsElastinExtracellular Matrix ProteinsFbln5 protein, mouseRecombinant ProteinsBiomechanicsCervixContractilityElastic fibersImmunofluorescence

Identifiers

PMID42475954
PMCPMC13636348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.