Evidence map›Paper›PMID 42475584›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

The unique Efg1 fungal virulence regulon in the catheterized bladder environment.

Alyssa Ann La Bella, Nicholas C Gervais, Kurt N Kohler, Hope Akegbe, Chloe L P Obernuefemann, Christopher Gager, Catherine May May Hubbard, Armando M Marrufo, Ilse D Jacobsen, Rebecca S Shapiro and 4 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The unique Efg1 fungal virulence regulon in the catheterized bladder environment.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Alyssa Ann La Bella *Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.ORCID 0000-0001-7396-9670
Nicholas C Gervais *Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.ORCID 0000-0002-9971-0031
Kurt N KohlerDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.
Hope AkegbeDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.ORCID 0000-0001-5327-3801
Chloe L P ObernuefemannDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.
Christopher GagerDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.
Catherine May May HubbardDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.ORCID 0009-0006-5758-7772
Armando M MarrufoDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.
Ilse D JacobsenResearch Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Jena 07745, Germany.ORCID 0000-0002-6033-9984
Rebecca S ShapiroDepartment of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canada.
Michael G CaparonDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-1171-0772
Scott J HultgrenDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0001-8785-564X
Ana Lidia Flores-MirelesDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.
Felipe Hiram Santiago-TiradoDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556.ORCID 0000-0002-6453-4904

Funding

MOLECULAR BASIS OF E. COLI ADHESINS IN BLADDER DISORDERSR01DK051406 · NIDDK · WASHINGTON UNIVERSITY · PI SCOTT J. HULTGREN · 1997 to 2026
$8.8M
Understanding the role of catheter-associated protein deposition in the development of CAUTIR01DK128805 · NIDDK · UNIVERSITY OF NOTRE DAME · PI FLORES-MIRELES, ANA LIDIA, HOWELL, CAITLIN L · 2021 to 2025
$1.9M
Host and fungal factors important for the cryptococcal intracellular nicheR01AI177875 · NIAID · UNIVERSITY OF NOTRE DAME · PI Felipe H Santiago-Tirado · 2023 to 2026
$1.6M
The role of a pleiotropic drug resistance (PDR) transporter in the cryptococcal-host interactionsR21AI171742 · NIAID · UNIVERSITY OF NOTRE DAME · PI SANTIAGO-TIRADO, FELIPE H · 2023 to 2024
$430k
Elucidating fungal and bacterial polymicrobial interactions during catheter-associated urinary tract infectionsR21AI194476 · NIAID · UNIVERSITY OF NOTRE DAME · PI Ana Lidia Flores-Mireles · 2025 to 2026
$430k
HHS | NIH (NIH) R01AI177875HHS | NIH (NIH) R01DK051406HHS | NIH (NIH) R01DK128805HHS | NIH (NIH) R21AI171742NIAID NIH HHS R01 AI177875NIAID NIH HHS R21 AI171742NIAID NIH HHS R21 AI194476NIDDK NIH HHS R01 DK051406NIDDK NIH HHS R01 DK128805University of Notre Dame (ND) Start-up funds
6 · The paper itself

Abstract

Urinary catheterization, a frequent procedure in hospitals, nursing homes, and other healthcare facilities, is a primary driver of nosocomial infections. The most common of these are catheter-associated urinary tract infections (CAUTIs), which often progress to severe complication, sepsis, and ultimately death. The fungus

Indexed as

Candida albicansCandidiasisCatheter-Related InfectionsDNA-Binding ProteinsFungal ProteinsRegulonTranscription FactorsUrinary BladderUrinary Tract InfectionsAnimalsFemaleGene Expression Regulation, FungalHumansMiceVirulenceDNA-Binding ProteinsEFG1 protein, Candida albicansFungal ProteinsTranscription FactorsCandidaCAUTIEFG1fungal pathogenmedical devices

Identifiers

PMID42475584
PMCPMC13416844

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.