Evidence map›Paper›PMID 42475583›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Synergistic action of different molecular mechanisms causes striking levels of insecticide resistance in the malaria vector

Mengling Chen, Latifa Remadi, Dimitra Tsakireli, Emmanouil Kokkas, Sofia Balaska, Sibora Teta, Jocelyn M F Ooi, Janet Hemingway, Mark J I Paine, Gareth J Lycett and 2 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Synergistic action of different molecular mechanisms causes striking levels of insecticide resistance in the malaria vectorProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mengling ChenDepartment of Biology, University of Crete, Heraklion 70013, Greece.ORCID 0009-0004-2517-1807
Latifa RemadiInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 70013, Greece.
Dimitra TsakireliInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 70013, Greece.
Emmanouil KokkasDepartment of Biology, University of Crete, Heraklion 70013, Greece.
Sofia BalaskaInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 70013, Greece.
Sibora TetaDepartment of Biology, University of Crete, Heraklion 70013, Greece.
Jocelyn M F OoiVector Biology Department, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.
Janet HemingwayVector Biology Department, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.ORCID 0000-0002-3200-7173
Mark J I PaineVector Biology Department, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.
Gareth J LycettVector Biology Department, Liverpool School of Tropical Medicine, Liverpool L3 5QA, United Kingdom.ORCID 0000-0002-2422-053X
John VontasInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 70013, Greece.ORCID 0000-0002-8704-2574
Linda GrigorakiInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion 70013, Greece.

Funding

China Scholarship Council (CSC) 202306990018EC | HORIZON EUROPE Framework Programme (Horizon Europe) 101152599Hellenic Foundation for Research and Innovation (HFRI) 16044Hellenic Foundation for Research and Innovation (HFRI) 7406UKRI | Medical Research Council (MRC) MR/V001264/1
6 · The paper itself

Abstract

Intensifying insecticide resistance in the malaria vector

Indexed as

AnophelesInsecticide ResistanceInsecticidesMalariaMosquito VectorsAnimalsAnimals, Genetically ModifiedCytochrome P-450 Enzyme SystemFemaleInsect ProteinsMutationCytochrome P-450 Enzyme SystemInsecticidesInsect Proteinsfunctional geneticsmalariaresistance managementresistance mechanismssynergism

Identifiers

PMID42475583
PMCPMC13416335

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.