Evidence map›Paper›PMID 42475397›Full record

ArticlePLoS computational biology2026

Beyond memory capacity: A probabilistic, dual store model of visuospatial working memory.

Eduardo A Aponte, Thanneer M Perumal, Francesca Cormack, Christopher H Chatham

Abstract read
In one paragraph

Article in PLoS computational biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Eduardo A AponteRoche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.ORCID https://orcid.org/0009-0001-7978-4594
Thanneer M PerumalRoche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Francesca CormackCambridge Cognition, Cambridge, United Kingdom.
Christopher H ChathamRoche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The last decades have seen a great improvement in our understanding of visuospatial working memory (VSWM). Despite this progress, less is known about how information is stored, retained, and removed from VSWM when novel information is presented sequentially. Here, we present a novel computational model of the dynamics of VSWM that extends and improves classical ideas. Our analysis relies on data from three clinical trials involving neurotypicals and people with autism performing a smartphone based sequential VSWM task. In addition, we applied the model to data from a large clinical trial in prodromal Alzheimer's disease. We demonstrate that visual information in our sequential task is stored in independent pools of contrasting resources, with perfect and imperfect retrieval rates. Our findings illustrate how computational models combined with remote cognitive testing are mature enough for applications in large-scale clinical research.

Indexed as

Memory, Short-TermVisual PerceptionAlzheimer DiseaseAutistic DisorderComputational BiologyComputer SimulationHumansModels, Statistical

Identifiers

PMID42475397
PMCPMC13475967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.