Evidence map›Paper›PMID 42475339›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Sema3E-plexinD1 Axis Is a Modulator of Foxp3

Mojdeh Matloubi, Chukwunonso Onyilagha, Lianyu Shan, Sujata Basu, Andrew J Halayko, Mohamed Almiski, Abdelilah S Gounni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mojdeh MatloubiDepartment of Immunology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Chukwunonso OnyilaghaDepartment of Immunology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Lianyu ShanDepartment of Immunology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Sujata BasuDepartment of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Andrew J HalaykoDepartment of Physiology and Pathophysiology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.ORCID https://orcid.org/0000-0002-7865-4552
Mohamed AlmiskiDepartment of Anatomy, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Abdelilah S GounniDepartment of Immunology, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.

Funding

Canadian Institutes of Health Research (CIHR) PJT 173291
6 · The paper itself

Abstract

Airway epithelial cells (AEC) are the primary sources of Semaphorin3E (Sema3E) in human airways and its expression is downregulated in severe asthmatics, underscoring the AEC-derived Sema3E critical role in lung homeostasis. Here, we investigated the effects of AEC-derived Sema3E on immune responses in an acute house dust mite (HDM) asthma model. Transgenic Sema3E overexpression in AECs, using tamoxifen-inducible Scgb1a1Cre, did not alter lung neutrophils, eosinophils, macrophages, dendritic cells, B cells, and CD4 T-cell number and BALF cytokine levels. However, it significantly increased lung Foxp3

Indexed as

AsthmaForkhead Transcription FactorsPyroglyphidaeSemaphorinsT-Lymphocytes, RegulatoryAnimalsDisease Models, AnimalFemaleLungMiceMice, Inbred C57BLMice, KnockoutSignal TransductionForkhead Transcription FactorsFoxp3 protein, mouseSema3e protein, mouseSemaphorinsairway epithelial cellsairway hyperresponsivenessairway inflammationairway remodelingasthmaPlexinD1regulatory T cellSemaphorin3E

Identifiers

PMID42475339
PMCPMC13384266

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.