SynthesisEchocardiography (Mount Kisco, N.Y.)2026
Disease-Phase Myocardial Dysfunction by Strain Imaging in Kawasaki Disease: A Systematic Review and Meta-Analysis.
Synthesis in Echocardiography (Mount Kisco, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundGlobal longitudinal strain (GLS) can detect subclinical dysfunction missed by left ventricular ejection fraction (LVEF). We aim to quantify the magnitude of myocardial dysfunction using GLS across the phases of Kawasaki disease (KD).
methodWe systematically searched for studies comparing GLS measurements between children with KD and age-matched controls. Effect sizes were pooled using a random-effects model and reported as standardized mean differences (SMD) for the acute and chronic disease phases. SMDs were re-expressed as mean differences (MDs) using pooled weighted standard deviations (SDs) of 2.75% and 1.89% for the control groups in the acute and chronic phases, respectively.
resultsWe included 18 observational studies comprising 907 KD patients and 764 controls. KD patients demonstrated significant GLS depression compared with controls in both the acute (SMD: 1.34, 95% CI: 0.73, 1.95, p < 0.0001, I
conclusionsDespite LVEF normalization in the chronic phase of KD, myocardial dysfunction persists. This could be essential for long-term monitoring algorithms.
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