Evidence map›Paper›PMID 42474976›Full record

ArticleMolecular and cellular biochemistry2026

Hypoxia and endothelial interaction cooperatively amplify free fatty acid receptor 1 (FFAR1)-mediated malignancy in highly invasive lung cancer cells.

Shion Nagano, Yuka Kusumoto, Moemi Tamura, Nanami Shimomura, Hinata Amano, Mahiro Yanome, Nozomi Kano, Mizuki Ishida, Miwa Kawamoto, Toshifumi Tsujiuchi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shion NaganoDivision of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, 577-8502, Japan.
Yuka KusumotoDivision of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, 577-8502, Japan.
Moemi TamuraDivision of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, 577-8502, Japan.
Nanami ShimomuraDivision of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, 577-8502, Japan.
Hinata AmanoDivision of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, 577-8502, Japan.
Mahiro YanomeDivision of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, 577-8502, Japan.
Nozomi KanoDivision of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, 577-8502, Japan.
Mizuki IshidaDivision of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, 577-8502, Japan.
Miwa KawamotoDivision of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, 577-8502, Japan.
Toshifumi TsujiuchiDivision of Molecular Oncology, Department of Life Science, Faculty of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, 577-8502, Japan. ttujiuch@life.kindai.ac.jp.

Funding

Japan Society for the Promotion of Science 21K07109
6 · The paper itself

Abstract

Free fatty acid receptor (FFAR)-mediated signaling plays a critical role in cancer pathogenesis. Within the tumor microenvironment (TME), stromal cells support cancer cell functions under hypoxic conditions, thereby promoting malignant progression. This study investigated whether FFAR1 contributes to stromal cell-induced malignancy in cancer cells under hypoxic conditions (1% O

Indexed as

Endothelial CellsLung NeoplasmsNeoplasm ProteinsReceptors, G-Protein-CoupledA549 CellsAnimalsCell HypoxiaHumansMiceNeoplasm InvasivenessFFAR1 protein, humanNeoplasm ProteinsReceptors, G-Protein-CoupledCell invasionEndothelial cellsFFAR1HypoxiaLung cancer cells

Identifiers

PMID42474976
PMCPMC13638737

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.