Evidence map›Paper›PMID 42474903›Full record

ArticleJournal of cardiovascular translational research2026

Impact of Microaxial Flow Pump on Coronary Flow Dynamics in Normal Hearts: An Experimental Evaluation.

Tomoaki Ito, Keita Saku, Kenta Ohba, Takuya Nishikawa, Hiroki Matsushita, Masahiro Otake, Shohei Yokota, Kei Sato, Hidetaka Morita, Nana Hiraki and 6 more

Abstract read
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In one paragraph

Article in Journal of cardiovascular translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Tomoaki ItoDepartment of Clinical Engineering, Kokura Memorial Hospital, Kitakyushu, Japan.
Keita SakuDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, 564-8565, Osaka, Japan. saku.keita@ncvc.go.jp.ORCID 0000-0002-6856-9362
Kenta OhbaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, 564-8565, Osaka, Japan.
Takuya NishikawaDepartment of Research Promotion and Management, National Cerebral and Cardiovascular Center, Suita, Japan.
Hiroki MatsushitaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, 564-8565, Osaka, Japan.
Masahiro OtakeDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, 564-8565, Osaka, Japan.
Shohei YokotaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, 564-8565, Osaka, Japan.
Kei SatoDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, 564-8565, Osaka, Japan.
Hidetaka MoritaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, 564-8565, Osaka, Japan.
Nana HirakiDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, 564-8565, Osaka, Japan.
Yuki YoshidaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, 564-8565, Osaka, Japan.
Masafumi FukumitsuDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, 564-8565, Osaka, Japan.
Toru KawadaDepartment of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, 6-1 Kishibe-Shimmachi, Suita, 564-8565, Osaka, Japan.
Midori KakuuchiDepartment of Clinical Engineering, Osaka University Hospital, Suita, Japan.
Takaaki MaruhashiDepartment of Emergency and Critical Care Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Tadayoshi MiyamotoGraduate School of Human Environment, Osaka Sangyo University, Osaka, Japan.

Funding

Abiomed AbiomedJapan Agency for Medical Research and Development 24-B-7, 25-6-3Japan Science and Technology Agency JPMJPF2018Japan Society for the Promotion of Science 23K08449, 24K00885, 24K11283, 25K22628, 25K12304, 26K19296NTT Research, Inc. NTT Research, Inc.
6 · The paper itself

Abstract

The effects of microaxial flow pump (mAFP) support on coronary flow (CF) are well characterized in failing hearts, but its impact on CF in normal hearts under different levels of left ventricular (LV) unloading remains unclear. Seven anesthetized Saanen goats underwent left thoracotomy, and an Impella 5.5 device was implanted via the left common carotid artery and operated at incremental support levels: Control (P1-2), Partial (P4-6), and Total (P7-9). Coronary perfusion pressure (CPP), coronary vascular resistance (CVR), myocardial oxygen consumption (MVO₂), and diastolic LV wall stress were calculated at each level. With increasing mAFP support, CPP increased whereas CF decreased by 32.1% from Control to Total support (69.6 ± 19.8 vs. 48.4 ± 21.1 mL/min), and CVR increased 260% (0.5 ± 0.2 vs. 1.8 ± 1.3 mmHg·min/mL). In normal hearts, mAFP elevates CPP but paradoxically reduces CF due to increased CVR associated with LV unloading.

Indexed as

Coronary CirculationCoronary VesselsHeart-Assist DevicesVentricular Function, LeftAnimalsGoatsMiniaturizationModels, AnimalMyocardiumOxygen ConsumptionProsthesis DesignStress, MechanicalTime FactorsVascular ResistanceCoronary flowLeft ventricular unloadingMicroaxial flow pumpMyocardial oxygen consumptionNormal heart

Identifiers

PMID42474903

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.