Evidence map›Paper›PMID 42474758›Full record

ReviewMolecular biology reports2026

Acidic nuclear phosphoprotein 32A (ANP32A): structure, function, and its role in disease pathogenesis.

Zhiqi Zhang, Enjie Liu, Zeyuan Wang, Yajun Huo, Yifan Shang, Huimin Du, Jun Yu, Wencai Li

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhiqi ZhangDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Enjie LiuDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Zeyuan WangDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Yajun HuoDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Yifan ShangDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Huimin DuDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Jun YuDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China.
Wencai LiDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. liwencaipatho@126.com.

Funding

Henan Clinical Medical Scientist Program HNCMS202429Henan Provincial Young and Middle-aged Talent Program for Health Science and Technology Innovation JQRC2024009Natural Science Foundation of Henan Province 242300421081
6 · The paper itself

Abstract

Acidic nuclear phosphoprotein 32A (ANP32A) is not only a core component of the inhibitor of histone acetyltransferases (INHAT) complex but also a crucial pleiotropic protein regulating cellular homeostasis and disease progression. Its extensive involvement in transcriptional regulation, apoptotic cascades, and signal transduction underpins its pivotal role across virology, neurobiology, and oncology. This review systematically elucidates the structure-function relationship of ANP32A, delineating its role as an essential host factor for viral replication​ and its complex involvement in neurodegenerative processes. Particular emphasis is placed on its context-dependent duality within oncology, where it exerts a pronounced "double-edged sword" effect by acting as either a tumor suppressor or an oncogene depending on the cellular milieu. Ultimately, this article aims to provide a theoretical foundation for the development of precision-targeted clinical interventions directed at ANP32A.

Indexed as

Nuclear ProteinsAnimalsHumansNeoplasmsRNA-Binding ProteinsSignal TransductionStructure-Activity RelationshipVirus ReplicationANP32A protein, humanNuclear ProteinsRNA-Binding ProteinsANP32ACancerEpigenetic regulationNeurological disordersPP2AVirus

Identifiers

PMID42474758

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.