ArticlePediatric nephrology (Berlin, Germany)2026
Major adverse kidney events at pediatric intensive care unit discharge in a nationwide Japanese pediatric continuous kidney replacement therapy registry.
Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMajor adverse kidney events (MAKE)-a composite of death, new dialysis dependence, and persistent kidney dysfunction-are key outcomes in pediatric patients receiving continuous kidney replacement therapy (CKRT). Due to limited Asian pediatric population data, we determined MAKE incidence at pediatric intensive care unit (PICU) discharge and explored associated factors using the first nationwide Japanese pediatric continuous renal replacement therapy (jpCRRT) registry.
methodsThis cohort study included children (aged < 16 years) who underwent CKRT for acute conditions between 2023 and 2025 in 17 Japanese PICUs. The primary outcome, MAKE at PICU discharge, was defined as death, new dialysis dependence, or persistent kidney dysfunction (≥ 25% increase in serum creatinine from baseline or ≥ 25% decrease in estimated glomerular filtration rate). Multivariable logistic regression, with variable selection using the least absolute shrinkage and selection operator and adjustment for clinically relevant covariates, was used to identify independent predictors of MAKE.
resultsOf 139 patients, 76 (54.7%) developed MAKE, comprising death, new dialysis dependence, and persistent kidney dysfunction in 25 (18.0%), 18 (13.0%), and 33 (23.7%), respectively. Independent MAKE factors were primary admission diagnoses of kidney disease (adjusted odds ratio (AOR), 60.7; 95% confidence interval (CI), 5.8-639), infection/sepsis (AOR, 37.0; 95% CI, 3.7-373), higher vasoactive-inotropic score (per 1-point increase; AOR, 1.04; 95% CI, 1.004-1.08), and hyperkalemia (per 1 mmol/L increase; AOR, 2.0; 95% CI, 1.1-3.6). High vasoactive support and hyperkalemia were associated with mortality, whereas kidney and infectious admission diagnoses were associated with new dialysis dependence or persistent kidney dysfunction.
conclusionAmong children receiving CKRT, more than half experienced MAKE at PICU discharge. Notably, a primary admission diagnosis of kidney disease was associated with adverse short-term outcomes, along with infectious/septic admission diagnoses, higher vasoactive-inotropic scores, and hyperkalemia. Longer-term follow-up is needed to clarify subsequent kidney recovery and post-discharge outcomes.
Indexed as
Identifiers
42474745What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.