ArticleInternational microbiology : the official journal of the Spanish Society for Microbiology2026
Hidden in the community: poly-clonal spread of KPC- or NDM-producing Klebsiella pneumoniae revealed by whole-genome sequencing in Southeastern Brazil.
Article in International microbiology : the official journal of the Spanish Society for Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesCarbapenemase-producing Klebsiella pneumoniae remains a major driver of multidrug resistance, traditionally linked to healthcare-associated infections but its detection in community-acquired infections represents a worrying shift. We aimed to characterize community-origin KPC- or NDM-producing K. pneumoniae isolates from two cities in São Paulo State, Brazil.
methodsA laboratory-based surveillance was conducted, including 111 non-duplicate K. pneumoniae isolates from urine of non-hospitalized patients. Polymyxin B MICs were determined by broth microdilution. All isolates underwent Illumina WGS. In silico analyses used Kleborate and Roary were used for bioinformatics analyses.
results76% of the isolates were susceptible to polymyxin. The most frequent carbapenemase gene detected was KPC-2 (94.5%), but KPC-3, NDM-1 and NDM-5 were detected. MLST showed high clonal diversity (14 STs), dominated by ST11 (n = 34) and ST437 (n = 20), followed by ST16 (n = 12), ST6386 (n = 10), ST258 (n = 9), ST147 (n = 6), ST307 (n = 5), among others. Core-genome phylogeny revealed a polyclonal structure with multiple subclusters, consistent with community dissemination, grouped by ST. No classic hvKp plasmid markers were detected by Kleborate. Resistome were diverse.
conclusionsThe predominance of CC11-related lineages (including ST11, ST437, and ST6386) indicates the persistence of the pandemic K. pneumoniae clone historically associated with bla
Indexed as
Identifiers
42474693What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.