Evidence map›Paper›PMID 42474600›Full record

ReviewJournal of robotic surgery2026

Robotic surgery for rectal cancer in 2026: a hierarchical appraisal of the evidence.

Pedro Silva-Vaz, Mariana Belo Cruz, José Guilherme Tralhão

Abstract readReview
In one paragraph

Review in Journal of robotic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pedro Silva-VazGeneral Surgery Department, Coimbra University Hospitals, Unidade Local de Saúde de Coimbra, Coimbra, 3000-075, Portugal. 17536@ulscoimbra.min-saude.pt.ORCID http://orcid.org/0000-0002-2979-1024
Mariana Belo CruzGeneral Surgery Department, Coimbra University Hospitals, Unidade Local de Saúde de Coimbra, Coimbra, 3000-075, Portugal.ORCID http://orcid.org/0000-0003-4653-9004
José Guilherme TralhãoGeneral Surgery Department, Coimbra University Hospitals, Unidade Local de Saúde de Coimbra, Coimbra, 3000-075, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Robotic total mesorectal excision (TME) now rests on an evidence base that has accumulated layer by layer: randomized trials, meta-analyses, registry cohorts, and dedicated functional-outcomes studies. The publication of the long-term results of the REAL trial (2025) marked a turning point. We propose a hierarchical evidence framework in which the REAL trial functions as confirmatory apex rather than foundational basis. It provided the first randomized evidence of better locoregional control and disease-free survival with robotic surgery compared to laparoscopy (3-year locoregional recurrence 1.6% vs. 4.0%; absolute risk reduction 2.4%; HR 0.45). This narrative review synthesizes the current evidence comparing robotic TME with laparoscopic TME, framing the most recent randomized data within the broader context of the accumulated literature. Across multiple study designs, robotic TME is consistently associated with lower conversion rates, better circumferential resection margin negativity in selected subgroups, and better preservation of urinary and sexual function. These advantages are amplified in male patients, those with obesity, post-neoadjuvant fibrosis, and lower rectal tumors. Important caveats remain: REAL was conducted exclusively at high-volume Chinese centers, an overall survival benefit has not yet been demonstrated, and cost and access barriers continue to shape global adoption. Evidence in 2026 supports robotic TME as the preferred minimally invasive approach for mid-to-low rectal cancer in centers with established expertise, adequate infrastructure, and case volume. When these conditions are not met, expert laparoscopic TME retains its place. Five-year data and validation across diverse healthcare systems are needed before a universal recommendation can be made.

Indexed as

Rectal NeoplasmsRobotic Surgical ProceduresColorectal Surgical ProceduresHumansLaparoscopyRandomized Controlled Trials as TopicCost-effectivenessFunctional outcomesRectal CancerRobotic SurgeryStandard of CareTotal Mesorectal Excision

Identifiers

PMID42474600
PMCPMC13385172

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.