Evidence map›Paper›PMID 42474504›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Smoking reshapes systemic metabolic coordination across lung cancer subtypes: a multicenter total-body

Haiyan Wang, Yaping Wu, Yanhua Duan, Lianghua Li, Lubing Sun, Xuetong Tao, Na Zhang, Xiaowen Zhao, Jianjun Liu, Zilong Guan and 11 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Whole-bodyEuropean journal of nuclear medicine and molecular imaging · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Haiyan Wang *Biomedical Imaging Laboratory (BIG), Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Taipa, Macau SAR, 999078, China.
Yaping Wu *Department of Medical Imaging, Henan Provincial People's Hospital & People's Hospital of Zhengzhou University, Zhengzhou, 450003, China.
Yanhua Duan *Department of PET/CT, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, Shandong, China.
Lianghua Li *Department of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 201807, China.
Lubing SunDepartment of Medical Imaging, Henan Provincial People's Hospital & People's Hospital of Zhengzhou University, Zhengzhou, 450003, China.
Xuetong TaoResearch Center for Medical AI, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Na ZhangResearch Center for Medical AI, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Xiaowen ZhaoDepartment of PET/CT, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, Shandong, China.
Jianjun LiuDepartment of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 201807, China.
Zilong GuanResearch Center for Medical AI, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Wanwan GuoResearch Center for Medical AI, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Yuxi JinResearch Center for Medical AI, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Zixiang ChenResearch Center for Medical AI, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Wenbo LiResearch Center for Medical AI, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Hairong ZhengResearch Center for Medical AI, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Dong LiangResearch Center for Medical AI, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Ruohua ChenDepartment of Nuclear Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 201807, China. crh19870405@163.com.
Zhaoping ChengDepartment of PET/CT, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, Shandong, China. czpabc@163.com.
Meiyun WangDepartment of Medical Imaging, Henan Provincial People's Hospital & People's Hospital of Zhengzhou University, Zhengzhou, 450003, China. mywang@zzu.edu.cn.
Greta S P MokBiomedical Imaging Laboratory (BIG), Department of Electrical and Computer Engineering, Faculty of Science and Technology, University of Macau, Taipa, Macau SAR, 999078, China. gretamok@um.edu.mo.
Zhanli HuResearch Center for Medical AI, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China. zl.hu@siat.ac.cn.ORCID http://orcid.org/0000-0003-0618-6240

Funding

Guangdong Basic and Applied Basic Research Foundation of China 2023B1515120007Guangdong Basic and Applied Basic Research Foundation of China 2024B1515040018Joint Research Grant from the Science and Technology Development Fund of Macau 0178/2024/AMJNational Key Research and Development Program of China 2024YFE0202400National Natural Science Foundation of China 12326607National Natural Science Foundation of China 82372038Research Instrument Development Project of the Chinese Academy of Sciences PTYQ2026YZ0034Shenzhen Science and Technology Program of China KJZD20240903101307010
6 · The paper itself

Abstract

purposeLung cancer (LC) is increasingly recognized as a systemic disease, and these systemic alterations may differ across histological subtypes. Smoking is a major risk factor for LC, yet its impact on systemic metabolism across LC subtypes remains underexplored.

methodsWe studied 125 LC patients and 200 healthy controls from three centers who underwent static and dynamic total-body

resultsPopulation- and individual-level network analyses showed that smoking status was associated with altered systemic metabolic coordination in a subtype-dependent manner, with the liver consistently emerging as a central hub of metabolic disruption. Tumor habitat analysis further revealed a smoking-associated shift toward hypometabolic tumor microenvironments.

conclusionThese findings provide quantitative insight into smoking status-related systemic metabolic reprogramming in LC and highlight the potential value of imaging-based characterization across histological subtypes.

Indexed as

Fluorodeoxyglucose F18Lung NeoplasmsPositron Emission Tomography Computed TomographySmokingTumor MicroenvironmentWhole Body ImagingAgedCase-Control StudiesFemaleHumansMaleMiddle AgedFluorodeoxyglucose F18Lung cancerMetabolic networkSmokingTotal-body PET/CTTumor habitat imaging

Identifiers

PMID42474504

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.