Evidence map›Paper›PMID 42474298›Full record

ArticleeLife2026

Organization of circuits linking descending input to motor output in the

Han S J Cheong, Katharina Eichler, Tomke Stürner, Samuel K Asinof, Andrew S Champion, Elizabeth C Marin, Tess B Oram, Marissa Sumathipala, Lalanti Venkatasubramanian, Shigehiro Namiki and 6 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Inhibitory circuits control leg movements duringbioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Sexual dimorphism in the complete connectome of thebioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Shorter-duration escapes driven byProceedings. Biological sciences · 2025
    Article
  19. Article
  20. Inhibitory control explains locomotor statistics in walkingProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Han S J Cheong *Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID https://orcid.org/0000-0001-5233-3438
Katharina Eichler *<italic>Drosophila</italic> Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0002-7833-8621
Tomke Stürner *<italic>Drosophila</italic> Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0003-4054-0784
Samuel K AsinofJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID https://orcid.org/0009-0000-8793-4671
Andrew S Champion<italic>Drosophila</italic> Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0002-6883-0081
Elizabeth C Marin<italic>Drosophila</italic> Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0001-6333-0072
Tess B OramJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Marissa SumathipalaJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Lalanti Venkatasubramanian<italic>Drosophila</italic> Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.
Shigehiro NamikiResearch Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan.ORCID https://orcid.org/0000-0003-1559-799X
Igor SiwanowiczJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID https://orcid.org/0000-0001-5819-1530
Marta Costa<italic>Drosophila</italic> Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0001-5948-3092
Stuart BergJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID https://orcid.org/0000-0002-0766-0488
Janelia FlyEM Project TeamJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Gregory S X E Jefferis<italic>Drosophila</italic> Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.ORCID https://orcid.org/0000-0002-0587-9355
Gwyneth M CardJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID https://orcid.org/0000-0002-7679-3639

Funding

Deutsche Forschungsgemeinschaft Walter-Benjamin-Fellowship STU 793/2-1MRC-LMB MC-U105188491National Science Foundation 2127379Wellcome TrustWellcome Trust 10.35802/220343Wellcome Trust 10.35802/221300
6 · The paper itself

Abstract

In most animals, a small number of descending neurons (DNs) connect the brain to circuits and motor neurons (MNs) in the nerve cord. To understand how brain signals generate behavior, it is critical to understand the organization of the neural pathways linking DNs to MNs. In companion papers, we introduced a densely reconstructed connectome of the

Indexed as

ConnectomeDrosophilaDrosophila melanogasterMotor NeuronsNerve NetNeural PathwaysAnimalsBrainMaleNeuronsconnectomeD. melanogasterDrosophilaescapeflightneural circuitneurosciencewalking

Identifiers

PMID42474298
PMCPMC13384506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.