Evidence map›Paper›PMID 42474214›Full record

ArticleGlobal spine journal2026

Impact of Renal Osteodystrophy on In-Hospital Outcomes Following Cervical Fusion: A National Inpatient Sample Study.

Rongxin Zhang, Yanda Du, Ying Xu, Jian Wang, Keyun Zhang, ZhiGang Ai

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Article in Global spine journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Rongxin ZhangDepartment of Health Management, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yanda DuDivision of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Ying XuDivision of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Jian WangDivision of Orthopaedic Surgery, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Keyun ZhangDepartment of Joint Sport Medicine, The First Affiliated Hospital of Hunan Medical College, Huaihua, Hunan, China.
ZhiGang AiDepartment of anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.ORCID 0009-0000-0836-179X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Study DesignRetrospective cross-sectional study.ObjectivesTo evaluate the association between renal osteodystrophy (ROD) and in-hospital outcomes following cervical fusion.MethodsWe performed a retrospective analysis of the National Inpatient Sample from 2016 to 2022. Adult patients undergoing cervical fusion were identified and categorized according to the presence or absence of ROD. Propensity score matching was used to balance baseline demographic, hospital, and comorbidity characteristics. Multivariable logistic regression was applied to assess in-hospital complications, and resource utilization was evaluated using length of stay and total hospital charges. A CKD-only sensitivity analysis was additionally performed by comparing patients with ROD and concomitant CKD codes against patients with CKD codes but without ROD.ResultsAfter matching, 576 ROD and 2,403 non-ROD patients were included. ROD was associated with higher risks of mechanical ventilation (OR 1.429, 95% CI 1.033-1.952), delirium (OR 2.043, 95% CI 1.197-3.386), thrombocytopenia (OR 1.585, 95% CI 1.148-2.163), and transfusion (OR 1.700, 95% CI 1.282-2.236) (all p < 0.05). ROD patients also had a longer length of stay (9 vs 5 days) and higher total hospital charges ($168,428 vs $133,017) (both p < 0.001). In the CKD-only sensitivity analysis, elevated risks persisted for delirium, transfusion, and thrombocytopenia, whereas the mechanical ventilation signal was attenuated.ConclusionsROD was associated with a higher burden of perioperative in-hospital complications and greater hospital resource utilization following cervical fusion. These findings suggest that patients with ROD may benefit from closer perioperative risk stratification and multidisciplinary monitoring, particularly with respect to bleeding risk and delirium prevention.

Indexed as

cervical fusionin-hospital complicationsnational inpatient samplerenal osteodystrophyresource utilization

Identifiers

PMID42474214
PMCPMC13385159

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.