Evidence map›Paper›PMID 42474193›Full record

ArticleApplied and environmental microbiology2026

A haloarchaeal VapBC toxin-antitoxin system: regulatory mechanism and role in establishing population heterogeneity to facilitate survival of subpopulations under stress conditions.

Dan He, Yuqi Lin, Yanyan Zhang, Yang Liu, Ping Li, Xin Su, Xiaoyi Qu, Yaru Liu, Xianyi Shao, Hongbo Wen and 5 more

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Dan HeHubei Key Laboratory of Cell Homeostasis, Wuhan University, College of Life Sciences, Wuhan, Hubei, China.
Yuqi LinHubei Key Laboratory of Cell Homeostasis, Wuhan University, College of Life Sciences, Wuhan, Hubei, China.
Yanyan ZhangHubei Key Laboratory of Cell Homeostasis, Wuhan University, College of Life Sciences, Wuhan, Hubei, China.
Yang LiuHubei Key Laboratory of Cell Homeostasis, Wuhan University, College of Life Sciences, Wuhan, Hubei, China.
Ping LiHubei Key Laboratory of Cell Homeostasis, Wuhan University, College of Life Sciences, Wuhan, Hubei, China.
Xin SuHubei Key Laboratory of Cell Homeostasis, Wuhan University, College of Life Sciences, Wuhan, Hubei, China.
Xiaoyi QuHubei Key Laboratory of Cell Homeostasis, Wuhan University, College of Life Sciences, Wuhan, Hubei, China.
Yaru LiuHubei Key Laboratory of Cell Homeostasis, Wuhan University, College of Life Sciences, Wuhan, Hubei, China.
Xianyi ShaoHubei Key Laboratory of Cell Homeostasis, Wuhan University, College of Life Sciences, Wuhan, Hubei, China.
Hongbo WenHubei Key Laboratory of Cell Homeostasis, Wuhan University, College of Life Sciences, Wuhan, Hubei, China.
Hongyi LuoHubei Key Laboratory of Cell Homeostasis, Wuhan University, College of Life Sciences, Wuhan, Hubei, China.
Yi WuHubei Key Laboratory of Cell Homeostasis, Wuhan University, College of Life Sciences, Wuhan, Hubei, China.
Fei GanHubei Key Laboratory of Cell Homeostasis, Wuhan University, College of Life Sciences, Wuhan, Hubei, China.ORCID 0000-0003-1670-5251
Xiao-Feng TangHubei Key Laboratory of Cell Homeostasis, Wuhan University, College of Life Sciences, Wuhan, Hubei, China.ORCID 0000-0003-4513-0389
Bing TangHubei Key Laboratory of Cell Homeostasis, Wuhan University, College of Life Sciences, Wuhan, Hubei, China.ORCID 0000-0002-6200-3720

Funding

National Natural Science Foundation of China 31970028National Natural Science Foundation of China 32370088National Natural Science Foundation of China 32470037
6 · The paper itself

Abstract

Toxin-antitoxin (TA) systems are ubiquitously distributed in bacteria and archaea and have been implicated in various functions such as plasmid maintenance, phage defense, biofilm formation, stress response, and persistence, but their regulatory mechanisms and roles in haloarchaea are largely unknown. In this study, we found that four of the eight putative VapBC TA systems of

Indexed as

Archaeal ProteinsHalobacteriaceaeHaloferax volcaniiToxin-Antitoxin SystemsAntitoxinsBacterial ToxinsGene Expression Regulation, ArchaealOperonStress, PhysiologicalAntitoxinsArchaeal ProteinsBacterial Toxinshaloarchaearegulationstress resistancetoxin-antitoxin systemVapBC

Identifiers

PMID42474193
PMCPMC13488343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.