Evidence map›Paper›PMID 42474184›Full record

ArticleJournal of virology2026

Nectin4 restricts pseudorabies virus infection by blocking gD-Nectin1 interaction.

Yi Wang, Zongyi Bo, Senhong Zhao, Tanveer Ali Fazlani, Fayu Yang, Zhengshan Feng, Tianxing Cao, Zhonghui Zhang, Wenchao Xue, Shuai Chen and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yi WangState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.ORCID 0009-0000-6357-4974
Zongyi BoJoint International Research Laboratory of Agriculture and Agri-Product Safety, Yangzhou University, College of Veterinary Medicine, The Ministry of Education of China, Yangzhou, China.
Senhong ZhaoDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, Sichuan Agricultural University, College of Veterinary Medicine, Chengdu, China.
Tanveer Ali FazlaniState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Fayu YangState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Zhengshan FengState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Tianxing CaoState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Zhonghui ZhangState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Wenchao XueState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Shuai ChenState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Yupan QiaoState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
Zixiang ZhuState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.ORCID 0000-0002-4093-9683
Genhong ChengDepartment of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, California, USA.ORCID 0000-0002-6713-2783
Yiping WangDepartment of Preventive Veterinary Medicine, Research Center for Swine Diseases, Sichuan Agricultural University, College of Veterinary Medicine, Chengdu, China.ORCID 0000-0002-3178-3752
Haixue ZhengState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.ORCID 0000-0001-6850-1379
Shilei ZhangState Key Laboratory of Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.ORCID 0009-0001-8964-5264

Funding

joint research foundation of gansu province 24JRRA804National Natural Science Foundation of China 32503014
6 · The paper itself

Abstract

The alphaherpesvirus IMPORTANCE: Interferon-stimulated genes (ISGs) are the major mediators of the host antiviral innate immunity, yet most remain functionally uncharacterized against alphaherpesviruses. Here, we identify interferon-stimulated Nectin4 (PVRL4) as a potent alphaherpesvirus restriction factor. By directly engaging the viral glycoprotein D (gD) and blocking its interaction with the entry receptor Nectin1, Nectin4 suppresses viral internalization. These findings broaden our understanding of the host-alphaherpesvirus interaction and highlight Nectin4 as a potential target for antiviral intervention against alphaherpesviruses.

Indexed as

Cell Adhesion MoleculesHerpesvirus 1, SuidNectinsPseudorabiesViral Envelope ProteinsAnimalsCell LineHEK293 CellsHost-Pathogen InteractionsHumansProtein BindingSwineVirus InternalizationCell Adhesion MoleculesNECTIN1 protein, humanNECTIN4 protein, humanNectinsViral Envelope ProteinsNectin4pseudorabies virusviral entryvirus-host interaction

Identifiers

PMID42474184
PMCPMC13483241

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.