Evidence map›Paper›PMID 42474183›Full record

ReviewJournal of virology2026

Future-use consent and human virome research: ethical challenges.

Inmaculada de Melo-Martín, Hetanshi Naik, Joseph Yracheta, Jennifer Li-Pook-Than

Abstract readReview
In one paragraph

Review in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Inmaculada de Melo-MartínDivision of Medical Ethics, Weill Cornell Medicine-Cornell University, New York, New York, USA.ORCID 0000-0001-8656-8497
Hetanshi NaikDepartment of Genetics, Stanford University, School of Medicine, Stanford, California, USA.
Joseph YrachetaNative Biodata Consortium, Eagle Butte, South Dakota, USA.
Jennifer Li-Pook-ThanDepartment of Genetics, Stanford University, School of Medicine, Stanford, California, USA.

Funding

VAST Center: Viromes Across Space(s) and TimeU54AG089334 · NIA · STANFORD UNIVERSITY · PI Christopher Edward Mason · 2025 to 2026
$13.3M
NIA NIH HHS U54 AG089334NIH HHS 1U54AG089334
6 · The paper itself

Abstract

Future-use consent frameworks enable broad research on biospecimens and now extend to human virome studies. However, virome research challenges the core assumptions underlying these consent models. We examine four dimensions of concern: evolving interpretive frameworks for biospecimens, the unforeseen sensitivity of viral findings, unanticipated downstream uses of samples, and unresolved questions regarding the return of results. These features call for updated governance capable of sustaining the ethical legitimacy of clinical research in rapidly evolving scientific landscapes.

Indexed as

Biomedical ResearchInformed ConsentViromeHumansethicsinformed consentvirome research

Identifiers

PMID42474183
PMCPMC13483288

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.