ArticleThe Journal of international medical research2026
The association between physical activity and metabolic dysfunction-associated steatotic liver disease: Evidence from the National Health and Nutrition Examination Survey and UK Biobank.
Article in The Journal of international medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
ObjectiveThere is limited prospective evidence on the association of physical activity with metabolic dysfunction-associated steatotic liver disease. We aimed to use data from two major databases to systematically quantify the correlation of physical activity with the risk of metabolic dysfunction-associated steatotic liver disease.MethodsThis study used data from the National Health and Nutrition Examination Survey (2007-2020) and UK Biobank. Initially, a cross-sectional study was conducted using the data from the National Health and Nutrition Examination Survey data to assess the links between physical activity and metabolic dysfunction-associated steatotic liver disease using weighted logistic regression analysis with appropriate sample weights to ensure national representativeness. Subsequently, Cox proportional hazards regression and restricted cubic splines models were applied to infer causality and evaluate the potential dose-response relationships in the UK Biobank cohort over a median follow-up period of 14.18 years. Additionally, subgroup and sensitivity analyses were conducted to test the robustness of the results.ResultsIn the National Health and Nutrition Examination Survey, higher physical activity levels were inversely associated with metabolic dysfunction-associated steatotic liver disease risk (odds ratio: 0.78, 95% confidence interval: 0.63-0.97). This finding was supported in the UK Biobank cohort (hazard ratio: 0.57, 95% confidence interval: 0.34-0.76). A nonlinear dose-response relationship existed between physical activity and metabolic dysfunction-associated steatotic liver disease (
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