Evidence map›Paper›PMID 42474106›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer.

Abigail R Fabiano, Allen C Luo, Paul Taufalele, Jenna A Dombroski, Ehsan Aalaei, Schyler J Rowland, Melissa S Cantú, Alexandria T Carter, Samantha V Knoblauch, Cynthia A Reinhart-King and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Abigail R FabianoDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Allen C LuoDepartment of Bioengineering, Rice University, Houston, Texas, USA.
Paul TaufaleleDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Jenna A DombroskiDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Ehsan AalaeiDepartment of Bioengineering, Rice University, Houston, Texas, USA.
Schyler J RowlandDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Melissa S CantúDepartment of Bioengineering, Rice University, Houston, Texas, USA.
Alexandria T CarterDepartment of Bioengineering, Rice University, Houston, Texas, USA.
Samantha V KnoblauchDepartment of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Cynthia A Reinhart-KingDepartment of Bioengineering, Rice University, Houston, Texas, USA.
Michael R KingDepartment of Bioengineering, Rice University, Houston, Texas, USA.ORCID https://orcid.org/0009-0006-4643-3663

Funding

Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8M
Translational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9M
Enabling Technology to Study Mechanosensitive and Mechanoresistant Cancer Cells in FlowR01CA256054 · NCI · VANDERBILT UNIVERSITY · PI KING, MICHAEL R. · 2021 to 2025
$1.8M
Cancer Prevention and Research Institute of Texas RR230029Genetic Design and Engineering Center (GDEC) at Rice University CPRIT RP210116National Science Foundation Graduate Research Fellowship 2021314768NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA256054NIDDK NIH HHS P30 DK058404United States National Institute of Health R01CA256054Vanderbilt Digestive Disease Research Center DK058404
6 · The paper itself

Abstract

It remains unclear how circulating tumor cells (CTCs) adapt to and survive mechanical forces in the bloodstream, including fluid shear stress (FSS), making it critical to define the mechanisms that enable their survival and promote metastasis. To model these forces, we generated "mechanoresistant" (MR) LNCaP and PC3 prostate cancer (PCa) cell lines by repeatedly exposing cells to high‑intensity (HI) FSS (3950 dyn/cm

Indexed as

calretininfluid shear stressmechanoresistantmechanotransductionmetastasis

Identifiers

PMID42474106
PMCPMC13383692

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.