Evidence map›Paper›PMID 42474037›Full record

ArticleeLife2026

RNA selectively modulates activity of virulent amyloid PSMα3 and host-defense LL-37 via phase separation and aggregation dynamics.

Bader Rayan, Eilon Barnea, Rinat Indig, Christian F Pantoja, Jesse Gayk, Yael Lupu-Haber, Alexander Upcher, Amir Argoetti, Jacob Aunstrup Larsen, Alexander Kai Buell and 2 more

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bader RayanDepartment of Biology, Technion - Israel Institute of Technology, Haifa, Israel.ORCID https://orcid.org/0000-0003-1408-2214
Eilon BarneaDepartment of Biology, Technion - Israel Institute of Technology, Haifa, Israel.ORCID https://orcid.org/0009-0004-7762-8880
Rinat IndigDepartment of Biology, Technion - Israel Institute of Technology, Haifa, Israel.ORCID https://orcid.org/0009-0003-3809-6642
Christian F PantojaGerman Center for Neurodegenerative Diseases, Göttingen, Germany.ORCID https://orcid.org/0000-0002-6349-4680
Jesse GaykCSSB Centre for Structural Systems Biology, Deutsches Elektronen-Synchrotron DESY, Hamburg, Germany.
Yael Lupu-HaberThe Life Sciences and Engineering Infrastructure Center, Technion-Israel Institute of Technology, Haifa, Israel.ORCID https://orcid.org/0000-0002-2601-4123
Alexander UpcherIlse Katz Institute for Nanoscale Science and Technology, Ben Gurion University of the Negev, Beer-Sheva, Israel.ORCID https://orcid.org/0000-0002-0910-6552
Amir ArgoettiDepartment of Biology, Technion - Israel Institute of Technology, Haifa, Israel.
Jacob Aunstrup LarsenDepartment of Biotechnology and Biomedicine, Technical University of Denmark DTU, Kongens Lyngby, Denmark.ORCID https://orcid.org/0000-0002-6782-0594
Alexander Kai BuellDepartment of Biotechnology and Biomedicine, Technical University of Denmark DTU, Kongens Lyngby, Denmark.ORCID https://orcid.org/0000-0003-1161-3622
Markus ZweckstetterGerman Center for Neurodegenerative Diseases, Göttingen, Germany.ORCID https://orcid.org/0000-0002-2536-6581
Meytal LandauDepartment of Biology, Technion - Israel Institute of Technology, Haifa, Israel.ORCID https://orcid.org/0000-0002-1743-3430

Funding

Deutsche Forschungsgemeinschaft INST 1525/26-1 FUGG (project number 600373)European Research Council 10.3030/101087140European Research Council 10.3030/101088163Forschungskooperation Niedersachsen - Israel, Volkswagenstiftung 76251-4659/2022 (ZN 4042)Israel Science Foundation 2111/20Novo Nordisk Foundation NNFSA17002839
6 · The paper itself

Abstract

Amyloid-forming peptides are increasingly recognized as dynamic regulators at the host-pathogen interface, yet how environmental factors control their assembly and activity remains poorly understood. Here, RNA acts as a concentration-dependent regulator of two sequence-related α-helical peptides with fundamentally different assembly behaviors: the cross-α amyloid-forming

Indexed as

AmyloidAntimicrobial Cationic PeptidesRNAStaphylococcus aureusVirulence FactorsCathelicidinsHumansProtein AggregatesAmyloidAntimicrobial Cationic PeptidesCathelicidinsProtein AggregatesRNAVirulence Factorsamyloidfibrilshost defensehumaninfectious diseasemicrobiologymolecular biophysicsPSMsRNAS. aureusstructural biologyvirulence

Identifiers

PMID42474037
PMCPMC13384500

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.