ArticleEpigenomics2026
DNA methylation quality control decisions, removed beta values, and their influence on epigenetic clocks.
Audrey L Kelly, Brandt Levitt, Allison Aiello, Chantel L Martin, Kathleen Mullan Harris, Lauren Gaydosh
Abstract read
In one paragraphArticle in Epigenomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Audrey L KellyCarolina Population Center, University of North Carolina, Chapel Hill, NC, USA.
Brandt LevittCarolina Population Center, University of North Carolina, Chapel Hill, NC, USA.
Allison AielloDepartment of Epidemiology, Columbia Aging Center, Mailman School of Public Health, Columbia University, New York, NY, USA.
Chantel L MartinCarolina Population Center, University of North Carolina, Chapel Hill, NC, USA.
Kathleen Mullan HarrisCarolina Population Center, University of North Carolina, Chapel Hill, NC, USA.
Lauren GaydoshCarolina Population Center, University of North Carolina, Chapel Hill, NC, USA.
Funding
Wave IV Data CollectionP01HD031921 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HARRIS, KATHLEEN MULLAN · 1994 to 2020
$86.1MNational Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VII Core ProjectU01AG071448 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT A HUMMER · 2021 to 2026
$40.2MNational Longitudinal Study of Adolescent to Adult Health (Add Health): Wave VI Cognition and Early Risk Factors for Dementia ProjectU01AG071450 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AIELLO, ALLISON E, HUMMER, ROBERT A · 2021 to 2025
$16.2MThe Add Health Epigenome Resource: Life course stressors and epigenomic modifications in adulthoodR01MD013349 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AIELLO, ALLISON E, HARRIS, KATHLEEN MULLAN · 2018 to 2022
$3.5MBiological Aging Across the Life Course: Harmonizing Cohort Biospecimen ArchivesR01AG071071 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, Lauren M Gaydosh · 2021 to 2026
$3.0MNetwork on Measurement of Biological RiskR24AG037898 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CRIMMINS, EILEEN M, SEEMAN, TERESA E · 2010 to 2014
$1.1MNIA NIH HHS R01 AG071071NIA NIH HHS R24 AG037898NIA NIH HHS U01 AG071448NIA NIH HHS U01 AG071450NICHD NIH HHS P01 HD031921NIMHD NIH HHS R01 MD013349
6 · The paper itselfAbstract
backgroundMeasures of biological aging based on DNA methylation (epigenetic clocks) are commonly used in research across the biological, health, and social sciences. Many decisions are made during the quality control (QC) of the data on which such clocks are based, generating removed beta values that must be accommodated in construction of the clocks.
methodsWe apply a range of detection
resultsWe find that both detection
conclusionWe recommend imputing removed beta values rather than leaving those CpGs out of clock calculations on a per-sample basis.
Indexed as
DNA MethylationEpigenesis, GeneticEpigenomicsCpG IslandsHumansQuality Controlbiological ageDNA methylationepigenetic clocksimputationmissing dataquality control
Identifiers
PMID42473819
PMCPMC13390533
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