ArticleFrontiers in genetics2026
Effects of prenatal transportation stress on liver gene expression in male and female Brahman calves.
Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The liver is a central regulator of metabolic and endocrine functions that support fetal growth and postnatal development. Prenatal stress can reprogram hepatic development in the offspring, potentially causing long-term changes in metabolism and production efficiency. However, the influence of prenatal stress on hepatic molecular function and resulting phenotypes in beef cattle remains poorly understood. Therefore, the objectives of this study were to evaluate phenotypic traits and liver tissue gene expression in Brahman heifer and bull calves from prenatal transportation stress (PNS) and control (Control) treatment groups. One group of pregnant Brahman cows were transported for a 2-h period every 20 (±5) d from 60 to 140 days of gestation. Another group of pregnant Brahman cows served as Control. Thirty-two calves, eight heifer and eight bull calves from the PNS and Control groups, respectively, were utilized. Calves were weighed at approximately 25 (±2) d of age. The following day, calves were euthanized, and liver tissues were harvested. Phenotypic traits evaluated include birth weight, harvest weight, liver weight, pen score, and liver weight:harvest weight. Interaction of sex and treatment did not explain substantial variation for any trait (
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