Evidence map›Paper›PMID 42473670›Full record

ArticleiScience2026

Single-cell transcriptomics reveals bladder microenvironment dynamics in Hunner type interstitial cystitis.

Fumihiko Urabe, Kentaro Yoshihara, Jun Nakayama, Yuta Hirano, Naoaki Watanabe, Hironori Suzuki, Miyaka Umemori, Kagenori Ito, Taro Igarashi, Shun Sato and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fumihiko UrabeDepartment of Urology, The Jikei University School of Medicine, Tokyo, Japan.
Kentaro YoshiharaDepartment of Urology, The Jikei University School of Medicine, Tokyo, Japan.
Jun NakayamaDivision of Cell Signaling and Informatics, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan.
Yuta HiranoLaboratory of Integrative Oncology, National Cancer Center Research Institute, Tokyo, Japan.
Naoaki WatanabeLaboratory of Integrative Oncology, National Cancer Center Research Institute, Tokyo, Japan.
Hironori SuzukiLaboratory of Integrative Oncology, National Cancer Center Research Institute, Tokyo, Japan.
Miyaka UmemoriDepartment of Clinical Laboratory Technology, Faculty of Medical Science, Juntendo University, Chiba, Japan.
Kagenori ItoDepartment of Urology, The Jikei University School of Medicine, Tokyo, Japan.
Taro IgarashiDepartment of Urology, The Jikei University School of Medicine, Tokyo, Japan.
Shun SatoDepartment of Pathology, The Jikei University School of Medicine, Tokyo, Japan.
Takahiro KimuraDepartment of Urology, The Jikei University School of Medicine, Tokyo, Japan.
Akira FurutaDepartment of Urology, The Jikei University School of Medicine, Tokyo, Japan.
Yusuke YamamotoLaboratory of Integrative Oncology, National Cancer Center Research Institute, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hunner type interstitial cystitis is a chronic inflammatory bladder disorder characterized by pain and severe lower urinary tract symptoms. Using single-cell RNA sequencing of Hunner lesions, non-Hunner lesions, and control bladder tissues, we characterized cellular states and intercellular communication within the bladder microenvironment. We identified a neuregulin enriched fibroblast population that was preferentially expanded in Hunner lesions and exhibited enhanced signaling toward basal epithelial cells through NRG and WNT pathways. In contrast, myofibroblast states were more prominent in non-Hunner lesions. Epithelial cells showed increased heterogeneity and differentiation toward inflammatory umbrella cell states, consistent with tissue remodeling. These findings define stromal and epithelial alterations across the diseased bladder and highlight fibroblast epithelial communication as a potential contributor to chronic inflammation and tissue remodeling in Hunner type interstitial cystitis.

Indexed as

fibroblast epithelial communicationinterstitial cystitissingle-cell RNA-seq

Identifiers

PMID42473670
PMCPMC13380760

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.