ArticleClinical ophthalmology (Auckland, N.Z.)2026
Precise Epithelium Removal for Ectatic Corneas Technique in Corneal Collagen Crosslinking (PERFECT-CXL): Technique Description and Clinical Outcomes.
Article in Clinical ophthalmology (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To describe clinical outcomes of a hybrid collagen crosslinking technique, Precise Epithelium Removal for Ectatic Corneas Technique Collagen Crosslinking (PERFECT-CXL) using tomography-guided hybrid partial central epithelium removal with peripheral epithelial disruption in keratoconus. Patients and Methods: A retrospective chart review of all previously untreated eyes that underwent PERFECT-CXL for keratoconus (KCN) by one surgeon from June 2018 to January 2023 at a single, tertiary care center. PERFECT-CXL utilizes a two-stage epithelial approach involving diffuse, across the entire cornea, roughening with an Ultracell LASIK Disc in order to create epithelial microerosions, followed by 45 minutes of loading with hypo-osmolar 0.146% riboflavin. After loading, epithelial debridement of an approximately 4-5mm zone is performed, centered over the cone, based on Pentacam tomographic localization, and the cornea is treated with pulsed UV-A irradiation. This hybrid method aims to optimize oxygen availability and targeted biomechanical stabilization while also aiming to promote faster visual recovery and an earlier return to contact lens wear. In this retrospective chart review, 362 eyes underwent PERFECT-CXL, of which 150 were previously untreated non-contact lens wearing keratoconic eyes. Outcomes measured at 6 months, 1, 2 and 3 years post-operatively included best spectacle-corrected visual acuity (BSCVA), maximum keratometry (K Results: At six months, one, two, and three years post-op, BSCVA was stable in 97.5% (n = 120), 95.7% (n = 93), 94.2% (n = 69), and 94.9% (n = 39) of eyes, respectively. At one, two, and three years post-op, 80.3% (n = 117), 88.2% (n = 93), 84.1% (n = 69), and 84.6% (n = 39) of eyes experienced stabilization in K Conclusion: Preliminary, retrospective results suggest that PERFECT-CXL can be a safe and effective technique in halting progression of KCN and can be utilized in various stages of keratoconus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.