ArticleClinical ophthalmology (Auckland, N.Z.)2026
Corneal Tomography Changes After Simultaneous Topical Application of Cyclosporine and Trehalose in Keratoconus Evaluated with an Artificial Intelligence Model.
Article in Clinical ophthalmology (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: To assess corneal tomography changes in keratoconus (KC) patients after long-term simultaneous use of topical cyclosporine and trehalose. Design: Retrospective observational study. Methods: Corneal tomography of 362 eyes with KC was performed using Pentacam (OCULUS Optikgerate Gmbh, Germany) at 1 Results: The mean follow-up time was 10.8 ± 6.01 months (range: 6 to 36 months). Based on a change in Kmax of 0.75, 1.0 and 1.25D criteria, more than 90% of the eyes were stable for each criterion at the last follow-up (initial classification). The AI model confirmed stability of corneal tomography in more than 95% of the eyes at the last follow-up (final classification). Conclusion: Most KC eyes had stable tomography findings between the first and last follow-up. Topical anti-inflammatory regimens may be useful for minimizing or eliminating KC progression.
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