Evidence map›Paper›PMID 42473638›Full record

ArticleFrontiers in toxicology2026

Aip mutation leads to significant alterations in gene expression, altered sensitivity to Ahr ligands, and early lethality in zebrafish.

Dante M Perone, Jane K La Du, Sibel I Karchner, Neelakanteswar Aluru, Spencer R Stinson, Lisa Truong, Mark E Hahn, Robyn L Tanguay

Abstract read
In one paragraph

Article in Frontiers in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Toxics · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dante M PeroneSinnhuber Aquatic Research Laboratory and the Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, United States.
Jane K La DuSinnhuber Aquatic Research Laboratory and the Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, United States.
Sibel I KarchnerDepartment of Biology, Woods Hole Oceanographic Institution, Woods Hole, MA, United States.
Neelakanteswar AluruDepartment of Biology, Woods Hole Oceanographic Institution, Woods Hole, MA, United States.
Spencer R StinsonSinnhuber Aquatic Research Laboratory and the Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, United States.
Lisa TruongSinnhuber Aquatic Research Laboratory and the Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, United States.
Mark E HahnDepartment of Biology, Woods Hole Oceanographic Institution, Woods Hole, MA, United States.
Robyn L TanguaySinnhuber Aquatic Research Laboratory and the Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, United States.

Funding

Research Experience and Training Coordination CoreP42ES016465 · NIEHS · OREGON STATE UNIVERSITY · PI Robyn L Tanguay · 2009 to 2026
$52.5M
MODE OF ACTION OF ENVIRONMENTAL TOXICANTST32ES007060 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt, Siva Kumar Kolluri · 1985 to 2026
$11.6M
Zebrafish Biomedical Research Facility CoreP30ES030287 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt · 2020 to 2026
$9.8M
Discovering Chemical Activity Networks-Predicting Bioactivity Based on StructureR35ES031709 · NIEHS · OREGON STATE UNIVERSITY · PI Robyn L Tanguay · 2021 to 2026
$5.2M
Mechanisms Controlling Sensitivity and Resistance to Dioxin-like Compounds: Role of AIPR01ES033888 · NIEHS · WOODS HOLE OCEANOGRAPHIC INSTITUTION · PI Mark E Hahn · 2022 to 2026
$3.2M
NIEHS NIH HHS P30 ES030287NIEHS NIH HHS P42 ES016465NIEHS NIH HHS R01 ES033888NIEHS NIH HHS R35 ES031709NIEHS NIH HHS T32 ES007060
6 · The paper itself

Abstract

Humans and other organisms are regularly exposed to chemical compounds that elicit toxicity through the aryl hydrocarbon receptor (AHR) signaling pathway. AHR agonists include polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and some natural products, pharmaceuticals, and endogenous compounds. Interindividual differences in sensitivity to AHR agonists exists. Several populations of Atlantic killifish (

Indexed as

5-nitroacenaphtheneAhR (aryl hydrocarbon receptor)BkFdifferential susceptibilitygene set enrichment analyses (GSEA)leflunomidePCB126RNA seq analysis

Identifiers

PMID42473638
PMCPMC13381021

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.