Evidence map›Paper›PMID 42473637›Full record

ArticleBrain communications2026

Soluble high-molecular-weight amyloid-β species derived from amyloid-β-laden brains induce cerebral β-amyloidosis.

Mayu Kashiwagi-Hakozaki, Hirokazu Uchigami, Yasushi Naka, Asuka Kokawa, Tatsuo Mano, Junki Cho, Kaoru Yamada, Akinori Miyashita, Norikazu Hara, Takeshi Ikeuchi and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Mayu Kashiwagi-HakozakiDepartment of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Hirokazu UchigamiDepartment of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Yasushi NakaDepartment of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Asuka KokawaDepartment of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Tatsuo ManoDepartment of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Junki ChoDepartment of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Kaoru YamadaDepartment of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.ORCID https://orcid.org/0000-0003-3696-0604
Akinori MiyashitaDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
Norikazu HaraDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
Takeshi IkeuchiDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.ORCID https://orcid.org/0000-0001-8828-8085
Alberto Serrano-PozoDepartment of Neurology, Alzheimer's Disease Research Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA.ORCID https://orcid.org/0000-0003-0899-7530
Matthew P FroschDepartment of Neurology, Alzheimer's Disease Research Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Bradley T HymanDepartment of Neurology, Alzheimer's Disease Research Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA.
Tatsushi TodaDepartment of Neurology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.ORCID https://orcid.org/0000-0002-0717-1123
Masashi FukayamaDepartment of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Tetsuo UshikuDepartment of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Tomoko WakabayashiDepartment of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Takeshi IwatsuboDepartment of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Tadafumi HashimotoDepartment of Neuropathology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spatiotemporal spreading of amyloid-β peptide deposition as senile plaques is a key pathogenic process in the brains of patients with Alzheimer's disease; however, the molecular properties of amyloid-β strains that initiate the spreading of amyloid-β peptide as aggregation seeds

Indexed as

in vivo seedingoligomerspropagationsenile plaquesβ-amyloidosis

Identifiers

PMID42473637
PMCPMC13381059

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.