Evidence map›Paper›PMID 42473541›Full record

ArticleMaterials today. Bio2026

Modelling cigarette smoke-induced lung vascular dysfunction using an alveolus-on-chip.

Abilash Ravi, Tarek Gensheimer, Annemarie van Schadewijk, Xinhui Wu, Jill R Johnson, Martin C Harmsen, Reinoud Gosens, Pieter S Hiemstra, Andries D van der Meer, Anne M van der Does

Abstract read
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In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abilash RaviPulmoScience Lab, Department of Pulmonology, Leiden University Medical Center, Leiden, 2333 ZA, the Netherlands.
Tarek GensheimerApplied Stem Cell Technologies, Department of Bioengineering Technologies, University of Twente, Enschede, 7522 AA, the Netherlands.
Annemarie van SchadewijkPulmoScience Lab, Department of Pulmonology, Leiden University Medical Center, Leiden, 2333 ZA, the Netherlands.
Xinhui WuDepartment of Molecular Pharmacology, Faculty of Science and Engineering, University of Groningen, Groningen, 9713 AV, the Netherlands.
Jill R JohnsonSchool of Biosciences, College of Health & Life Sciences, Aston University, Birmingham, B15 2TT, United Kingdom.
Martin C HarmsenDepartment of Molecular Pharmacology, Faculty of Science and Engineering, University of Groningen, Groningen, 9713 AV, the Netherlands.
Reinoud GosensDepartment of Molecular Pharmacology, Faculty of Science and Engineering, University of Groningen, Groningen, 9713 AV, the Netherlands.
Pieter S HiemstraPulmoScience Lab, Department of Pulmonology, Leiden University Medical Center, Leiden, 2333 ZA, the Netherlands.
Andries D van der MeerApplied Stem Cell Technologies, Department of Bioengineering Technologies, University of Twente, Enschede, 7522 AA, the Netherlands.
Anne M van der DoesPulmoScience Lab, Department of Pulmonology, Leiden University Medical Center, Leiden, 2333 ZA, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The alveolus is central to gas exchange in the lung, and alveolar damage is a characteristic of a variety of lung diseases. Understanding alveolar microvascular dynamics and epithelial-endothelial interactions is essential for accurately modeling alveolar physiology and its dysfunction in lung diseases such as Chronic Obstructive Pulmonary Disease (COPD). In this study, we present an open-top, membrane-free alveolus-on-chip platform incorporating self-assembled, perfusable 3D vascular networks by primary human lung endothelial cells and pericytes, co-cultured with alveolar epithelial type 2 (AEC2) cells. These vascular networks were developed within 6 days under continuous flow and remained stable for at least 12 days. The inclusion of pericytes supported capillary-like vessel formation and increased gene expression of

Indexed as

Alveolar epithelial cellsCigarette smokeCOPDEndothelial cellsLung-on-chipPericytes

Identifiers

PMID42473541
PMCPMC13380759

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.