ReviewCureus2026
Short- Versus Standard-Duration Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Acute Coronary Syndrome: A Systematic Review and Meta-Analysis.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dual antiplatelet therapy (DAPT) for 12 months has historically been the standard of care following percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS); however, prolonged DAPT carries a cumulative, time-dependent risk of major bleeding. We aimed to determine whether a short DAPT duration (≤6 months) followed by single antiplatelet therapy reduces bleeding events without compromising ischemic safety compared with standard 12-month DAPT in ACS patients. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) by searching Medical Literature Analysis and Retrieval System Online (MEDLINE), Excerpta Medica database (EMBASE), and Cochrane Controlled Register of Trials (CENTRAL) from inception to March 2026 for studies comparing short DAPT (≤6 months) versus standard DAPT (12 months) in adults undergoing PCI with drug-eluting stents for ACS. The co-primary endpoints were major bleeding and major adverse cardiovascular events (MACE), defined as a composite of death, myocardial infarction (MI), and stroke. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled using a DerSimonian-Laird random-effects model, with pre-specified subgroup analyses according to the type of P2Y12 inhibitor used during the monotherapy phase. Seven RCTs comprising 23,586 patients were included. Compared with standard 12-month DAPT, short DAPT significantly reduced the risk of major bleeding by 40% (HR 0.60, 95% CI 0.49-0.73; p<0.001), without a statistically significant increase in MACE (HR 1.02, 95% CI 0.88-1.17; p=0.79), all-cause mortality (HR 0.96, 95% CI 0.80-1.14; p=0.66), or stroke (HR 0.91, 95% CI 0.70-1.17; p=0.46). Subgroup analysis demonstrated a significant interaction by P2Y12 inhibitor type for MI (p=0.016) and MACE (p=0.033), whereby early transition to clopidogrel monotherapy was associated with an approximately two-fold increase in MI risk, whereas monotherapy with a potent P2Y12 inhibitor (e.g., ticagrelor) preserved ischemic safety without excess events. In conclusion, in patients with ACS undergoing PCI, abbreviated DAPT (≤6 months) optimizes net clinical benefit by substantially reducing major bleeding without increasing overall ischemic or mortality risk; however, this safety is critically dependent on the choice of maintenance antiplatelet agent, with potent P2Y12 inhibitor monotherapy representing a safe strategy and early de-escalation to clopidogrel conferring excess MI risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.