ArticleCureus2026
Association of Frailty Factors, Especially Handgrip Strength, With One-Year Clinical Prognosis Following Transcatheter Aortic Valve Implantation: A Retrospective Cohort Analysis.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFrailty is an important determinant of prognosis in older patients undergoing transcatheter aortic valve implantation (TAVI). However, because frailty is a multidimensional construct, the specific components that most strongly influence long-term outcomes remain unclear. This study aimed to identify the preoperative frailty components associated with one-year composite outcomes after TAVI. METHODS AND
resultsThis retrospective cohort study included 123 patients who underwent TAVI. Preoperative frailty was assessed using the Clinical Frailty Scale (CFS), and its components were evaluated across physical (handgrip strength and short physical performance battery (SPPB)) and nutritional (serum albumin) domains. Univariate and multivariate Cox proportional hazards analyses were performed using multivariate models adjusted for age and sex. During the one-year follow-up period, 32 events (all-cause death or rehospitalization) occurred. In the univariate analysis, preoperative frailty, defined as a Clinical Frailty Scale (CFS) score ≥ 5 (hazard ratio (HR): 2.11, p=0.032), and handgrip strength (HR: 0.95, p=0.034) were significantly associated with the outcomes. In the multivariate analysis, only handgrip strength remained an independent predictor (HR: 0.93, 95% confidence interval (CI): 0.88-0.98, p=0.006). Receiver operating characteristic (ROC) analysis identified an exploratory cutoff value of 13.3 kg (area under the curve=0.622), and Kaplan-Meier analysis showed significantly lower event-free survival in patients with low handgrip strength.
conclusionPreoperative handgrip strength was an independent predictor of the one-year post-TAVI outcomes. It may serve as a practical tool for risk stratification and individualized rehabilitation planning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.