ArticleJournal of biochemical and molecular toxicology2026
Ameliorative Effects of Silymarin on Ovarian Ischemia/Reperfusion Injury via Modulation of Oxidative Stress and Inflammatory Pathways.
Article in Journal of biochemical and molecular toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Ischemia/reperfusion (IR) injury secondary to ovarian torsion results in oxidative stress, inflammation, and structural damage to the ovary. Silymarin (SLY), a natural flavonoid complex, possesses potent antioxidant and anti-inflammatory effects. The present study was designed to evaluate the protective effects of SLY on ovarian IR injury. An experimental model of OIR was created, and animals were divided into Sham, OIR, and OIR + SLY groups. An acute single dose of silymarin (100 mg/kg) was given to the treatment group. Tissue and serum levels of TNF-α, IL-17, TGF-β1, and H
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